Category: Aging

94-Year-Old Applies for Patent on Slow-Hunch Solid State Battery

(p. 7) In 1946, a 23-year-old Army veteran named John Goodenough headed to the University of Chicago with a dream of studying physics. When he arrived, a professor warned him that he was already too old to succeed in the field.
Recently, Dr. Goodenough recounted that story for me and then laughed uproariously. He ignored the professor’s advice and today, at 94, has just set the tech industry abuzz with his blazing creativity. He and his team at the University of Texas at Austin filed a patent application on a new kind of battery that, if it works as promised, would be so cheap, lightweight and safe that it would revolutionize electric cars and kill off petroleum-fueled vehicles. His announcement has caused a stir, in part, because Dr. Goodenough has done it before. In 1980, at age 57, he coinvented the lithium-ion battery that shrank power into a tiny package.
We tend to assume that creativity wanes with age. But Dr. Goodenough’s story suggests that some people actually become more creative as they grow older. Unfortunately, those late-blooming geniuses have to contend with powerful biases against them.
. . .
Years ago, he decided to create a solid battery that would be safer. Of course, in a perfect world, the “solid-state” battery would also be low-cost and lightweight. Then, two years ago, he discovered the work of Maria Helena Braga, a Portuguese physicist who, with the help of a colleague, had created a kind of glass that can replace liquid electrolytes inside batteries.
Dr. Goodenough persuaded Dr. Braga to move to Austin and join his lab. “We did some experiments to make sure the glass was dry. Then we were off to the races,” he said.
Some of his colleagues were dubious that he could pull it off. But Dr. Goodenough was not dissuaded. “I’m old enough to know you can’t close your mind to new ideas. You have to test out every possibility if you want something new.”
When I asked him about his late-life success, he said: “Some of us are turtles; we crawl and struggle along, and we haven’t maybe figured it out by the time we’re 30. But the turtles have to keep on walking.” This crawl through life can be advantageous, he pointed out, particularly if you meander around through different fields, picking up clues as you go along. Dr. Goodenough started in physics and hopped sideways into chemistry and materials science, while also keeping his eye on the social and political trends that could drive a green economy. “You have to draw on a fair amount of experience in order to be able to put ideas together,” he said.

For the full commentary, see:
Kennedy, Pagan. “To Be a Genius, Think Like a 94-Year-Old.” The New York Times, SundayReview Section (Sun., APRIL 9, 2017): 7.
(Note: ellipsis added.)
(Note: the online version of the commentary has the date APRIL 7, 2017.)

Retiring Later Improves Health in Old Age

(p. 3) Despite what may seem like obvious benefits, scholars can’t make definitive statements about the health effects of working longer. The research is inherently difficult: Just as retirement can influence health, so can health influence retirement.
“I would say, in my experience, the research is mixed,” said Dr. Maestas of Harvard Medical School. “The studies I have seen tend to show that there are health benefits to working longer.”
As the economists Axel Börsch-Supan and Morten Schuth of the Munich Center for the Economics of Aging of the Max Planck Institute for Social Law and Social Policy put it in an article for the National Bureau of Economic Research, “Even disliked colleagues and a bad boss, we argue, are better than social isolation because they provide cognitive challenges that keep the mind active and healthy.”
Other studies have examined the impact of work and employment on the richness of social networks and social connectedness. The economists Eleonora Patacchini of Cornell University and Gary Engelhardt of Syracuse University tapped into a database of some 1,300 people from ages 57 to 85 that asked about their social networks in 2005 and 2010. After controlling for marital status, age, health and income, they concluded that people who continued to work enjoyed an increase in the size of their networks of family and friends of 25 percent. The social networks of retired people, on the other hand, shrank during the five-year period. In the study, the gains were found to be largely limited to women and older people with postsecondary education.

For the full commentary, see:
CHRISTOPHER FARRELL. “Retiring; Their Jobs Keep Them Healthy.” The New York Times, SundayBusiness Section (Sun., MARCH 5, 2017): 3.
(Note: the online version of the commentary has the date MARCH 3, 2017, and has the title “Retiring; Working Longer May Benefit Your Health.”)

The article by Börsch-Supan and Schuth, is:
Börsch-Supan, Axel, and Morten Schuth. “Early Retirement, Mental Health, and Social Networks.” In Discoveries in the Economics of Aging, edited by David A. Wise. Chicago: University of Chicago Press, 2014, pp. 225-50.

Self-Driving Cars Would Help Older Adults Continue to Live at Home

(p. B4) Single, childless and 68, Steven Gold has begun to think about future mobility and independence. Although in good health, he can foresee a time when he won’t be a confident driver, if he can drive at all. While he hopes to continue to live in his suburban Detroit home, he wonders how he will be able to get to places like his doctor’s office and the supermarket if his driving becomes impaired.
For Mr. Gold and other older adults, self-driving cars might be a solution.
The number of United States residents age 70 and older is projected to increase to 53.7 million in 2030, from 30.9 million in 2014, according to the Institute for Highway Safety. Nearly 16 million people 65 and older live in communities where public transportation is poor or nonexistent. That number is expected to grow rapidly as baby boomers remain outside of cities.
“The aging of the population converging with autonomous vehicles might close the coming mobility gap for an aging society,” said Joseph Coughlin, the director of the Massachusetts Institute for Technology AgeLab in Cambridge.
He said that 70 percent of those over age 50 live in the suburbs, a figure he expects to remain steady despite a recent rise in moves to urban centers. Further, 92 percent of older people want to age in place, he said.

For the full story, see:
MARY M. CHAPMAN. “Wheels; For the Aged, Self-Driving Cars Could Bridge a Mobility Gap.” The New York Times (Fri., March 24, 2017): B4.
(Note: the online version of the story has the date March 23, 2017, and has the title “Wheels; Self-Driving Cars Could Be Boon for Aged, After Initial Hurdles.”)

“Death Has Never Made Any Sense to Me”

(p. 10) . . . , Kinsley is intent on being wryly realistic about coping with illness and the terminal prospects ahead. He makes fun of a fellow boomer, Larry Ellison, the C.E.O. of Oracle, who has spent millions in a quest for eternal life, and who was quoted as saying, “Death has never made any sense to me.” Kinsley quips: “Actually the question is not whether death makes sense to Larry Ellison but whether Larry Ellison makes sense to death. And I’m afraid he does.”

For the full review, see:
PHILLIP LOPATE. “Senior Moments’.” The New York Times Book Review (Sun., APRIL 24, 2016): 10.
(Note: ellipsis added.)
(Note: the online version of the review has the date APRIL 18, 2016, and has the title “Michael Kinsley’s ‘Old Age: A Beginner’s Guide’.”)

The book under review, is:
Kinsley, Michael. Old Age: A Beginner’s Guide. New York: Tim Duggan Books, 2016.

Employers Less Likely to Hire Older Workers

(p. A3) Using a method of uncovering discrimination well known in economics, David Neumark, an economist at the University of California at Irvine, led a study that sent out 40,000 fake résumés to employers who had posted openings. Mr. Neumark and his co-authors found that résumés suggesting an applicant was 64 to 66 years old got a response 35 percent less often than résumés suggesting that the applicant was 29 to 31.
Labeling it discrimination is another matter, however. “The one thing that people always point out is that acceptability for age stereotyping is extremely high,” Mr. Neumark said. “The number of people who make age-related jokes are way more frequent than people who make race-related jokes. For whatever reason, the social stigma for age discrimination is really weak.”
Aside from fairness, evidence suggests that finding ways to keep older Americans working has benefits to the broader society: Working keeps older Americans happier, healthier and more mentally engaged. And forestalling retirement could relieve some of the pressure a large aging population places on this country’s social safety net.
“Governments all over the world are trying to figure how to get old people to stay at work longer,” Mr. Neumark said. “If we have discriminatory barriers, then all these reforms will be less effective.”

For the full story, see:
Quoctrung Bui. “As More Older People Look for Work, They Are Put Into ‘Old Person Jobs’.” The New York Times (Thurs., AUG. 18, 2016): A3.
(Note: the online version of the article has the title “More Older People Are Finding Work, but What Kind?”)

The Neumark paper mentioned above, is:
Neumark, David, Ian Burn, and Patrick Button. “Experimental Age Discrimination Evidence and the Heckman Critique.” American Economic Review 106, no. 5 (May 2016): 303-08.

Resveratrol Slows Alzheimer’s

(p. D1) A recent human study that suggested resveratrol could slow the progression of Alzheimer’s used a daily dose equivalent to the amount in about 1,000 bottles of red wine, says Scott Turner, director of the Memory Disorders Program at Georgetown University Medical Center, who led the study. Such high doses can lead to side effects such as nausea, vomiting and diarrhea.
Such side effects have caused past efforts to tap the health benefits of resveratrol to founder. GlaxoSmithKline PLC shelved a project to develop a resveratrol-based pill in 2010 after some clinical-trial patients developed kidney problems. The company, which had hoped to develop the drug as a treatment for a type of blood cancer, concluded that while resveratrol didn’t directly cause those problems, its side effects led to dehydration, which could exacerbate underlying kidney issues.
Now, scientists hope to overcome that problem by increasing the potency of resveratrol at more moderate doses. Researchers at the University of New South Wales, near Sydney, suspect the substance is more effective when accompanied by other ingredients found in red wine, which somehow promote its activity. They are developing a pill that combines puri-(p. D4)fied resveratrol with other compounds in wine in an effort to mimic the drink’s naturally-occurring synergies.
. . .
At the University of New South Wales, researchers have combined resveratrol with two other components of red wine: antioxidants and chelating agents, which have separately been shown also to have health benefits.
. . .
The researchers recently tried the combination in a small trial involving 50 people and found it increased the activity of a substance called NAD+ that plays a key role in maintaining healthy cells.

For the full story, see:
DENISE ROLAND. “Scientists Try to Put Red Wine in a Pill.” The Wall Street Journal (Tues., Aug. 2, 2016): D1 & D4.
(Note: ellipses added.)
(Note: the online version of the story has the date Aug. 1, 2016, and has the title “Scientists Get Closer to Harnessing the Health Benefits of Red Wine.”)

A recent article co-authored by Turner, related to the research summarized above, is:
Moussa, Charbel, Michaeline Hebron, Huang Xu, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen, R. Scott Turner, Xu Huang, and R. Scott Turner. “Resveratrol Regulates Neuro-Inflammation and Induces Adaptive Immunity in Alzheimer’s Disease.” Journal of Neuroinflammation 14 (Jan. 3, 2017): 1-10.

U.S. Forest Service Killed “Prometheus,” World’s Oldest Tree

(p. D9) Great Basin’s . . . big draw–trees about as old as Egyptian hieroglyphics–sits at the top of the sky island in Wheeler Peak Bristlecone Grove.
. . .
At the grove, a stand of weather-battered bristlecone pines await, just as they have for between 3,000 and 4,000 years. With their knobby trunks and gnarled branches, the trees look like characters in an animated film’s enchanted forest, ready to burst into song. They often have only a small strip of bark, with the rest of the trunk bare, exposing the smooth, rich browns, yellows and grays in its fine grain.
At one time the oldest known tree in the world lived here. Its dignified appearance earned it the name Prometheus. In 1964, two decades before Great Basin became a national park, a researcher, trying to collect data about the area’s climate history, drilled into defenseless Prometheus (not knowing its exact age) to examine its rings. When his coring instrument got stuck, the Forest Service felled the tree to retrieve his tool– only to discover that the tree was 4,900 years old.
Oops.

For the full story, see:
JIM ROBBINS. “In a Strange Land; One of the country’s least-hyped nature preserves, Nevada’s Great Basin National Park has a weird, wild beauty all its own.” The Wall Street Journal (Sat., MARCH 11, 2017): D9.
(Note: ellipses added.)
(Note: the online version of the story has the date MARCH 9, 2017, and has the title “A Hike Through America’s Otherworldly Outback.”)

“More Women in Their 60s and 70s” Work in Fulfilling Jobs

(p. 1) Kay Abramowitz has been working, with a few breaks, since she was 14. Now 76, she is a partner in a law firm in Portland, Ore. — with no intention of stopping anytime soon. “Retirement or death is always on the horizon, but I have no plans,” she said. “I’m actually having way too much fun.”
The arc of women’s working lives is changing — reaching higher levels when they’re younger and stretching out much longer — according to two new analyses of census, earnings and retirement data that provide the most comprehensive look yet at women’s career paths.
. . .
Most striking, women have become significantly more likely to work into their 60s and even 70s, often full time, according to the analyses. And many of these women report that they do it because they enjoy it.
. . .
Nearly 30 percent of women 65 to 69 are working, up from 15 percent in the late 1980s, one of the analyses, by the Harvard economists Claudia Goldin and Lawrence Katz, found. Eighteen per-(p. 4)cent of women 70 to 74 work, up from 8 percent.
. . .
Of those still working, Ms. Goldin said, “They’re in occupations in which they really have an identity.” She added, “Women have more education, they’re in jobs that are more fulfilling, and they stay with them.” (Ms. Goldin happens to be an example of the phenomenon, as a 70-year-old professor and researcher.)

For the full story, see:
Claire Cain Miller. “With More Women Fulfilled by Work, Retirement Has to Wait.” The New York Times, First Section (Sun., FEB. 12, 2017): 1 & 4.
(Note: ellipses added.)
(Note: the online version of the article has the date FEB. 11, 2017, and has the title “More Women in Their 60s and 70s Are Having ‘Way Too Much Fun’ to Retire.”)

The paper by Goldin and Katz, mentioned above, is:
Goldin, Claudia, and Lawrence F. Katz. “Women Working Longer: Facts and Some Explanations.” NBER Working Paper #22607. National Bureau of Economic Research, Inc., Sept. 2016.

Fitness Can Improve Even After Age 100

(p. D4) At the age of 105, the French amateur cyclist and world-record holder Robert Marchand is more aerobically fit than most 50-year-olds — and appears to be getting even fitter as he ages, according to a revelatory new study of his physiology.
The study, which appeared in December in The Journal of Applied Physiology, may help to rewrite scientific expectations of how our bodies age and what is possible for any of us athletically, no matter how old we are.
. . .
Conventional wisdom in exercise science suggests that it is very difficult to significantly add to aerobic fitness after middle age. In general, VO2 max, a measure of how well our bodies can use oxygen and the most widely accepted scientific indicator of fitness, begins to decline after about age 50, even if we frequently exercise.
But Dr. Billat had found that if older athletes exercised intensely, they could increase their VO2 max. She had never tested this method on a centenarian, however.
. . .
These data strongly suggest that “we can improve VO2 max and performance at every age,” Dr. Billat says.

For the full story, see:
GRETCHEN REYNOLDS. “Phys Ed; Lessons from a 105-Year-Old.” The New York Times (Tues., FEB. 14, 2017): D4.
(Note: ellipses added.)
(Note: the online version of the article has the date FEB. 8, 2017, and has the title “Phys Ed; Lessons on Aging Well, From a 105-Year-Old Cyclist.”)

The academic article mentioned in the passages quoted above, is:
Billat, Véronique, Gilles Dhonneur, Laurence Mille-Hamard, Laurence Le Moyec, Iman Momken, Thierry Launay, Jean Pierre Koralsztein, and Sophie Besse. “Case Studies in Physiology: Maximal Oxygen Consumption and Performance in a Centenarian Cyclist.” Journal of Applied Physiology 122 (2017): 430-34.

Mice Genome Reprogrammed to Rejuvenate Organs and Extend Life

(p. A22) At the Salk Institute in La Jolla, Calif., scientists are trying to get time to run backward.
Biological time, that is. In the first attempt to reverse aging by reprogramming the genome, they have rejuvenated the organs of mice and lengthened their life spans by 30 percent. The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.
The Salk team’s discovery, reported in the Thursday issue of the journal Cell, is “novel and exciting,” said Jan Vijg, an expert on aging at the Albert Einstein College of Medicine in New York.
Leonard Guarente, who studies the biology of aging at M.I.T., said, “This is huge,” citing the novelty of the finding and the opportunity it creates to slow down, if not reverse, aging. “It’s a pretty remarkable finding, and if it holds up it could be quite important in the history of aging research,” Dr. Guarente said.
. . .
Ten years ago, the Japanese biologist Shinya Yamanaka amazed researchers by identifying four critical genes that reset the clock of the fertilized egg. The four genes are so powerful that they will reprogram even the genome of skin or intestinal cells back to the embryonic state.
. . .
Dr. Izpisua Belmonte believes these beneficial effects have been obtained by resetting the clock of the aging process. The clock is created by the epigenome, the system of proteins that clads the cell’s DNA and controls which genes are active and which are suppressed.
. . .
Dr. Izpisua Belmonte sees the epigenome as being like a manuscript that is continually edited. “At the end of life there are many marks and it is difficult for the cell to read them,” he said.
What the Yamanaka genes are doing in his mice, he believes, is eliminating the extra marks, thus reverting the cell to a more youthful state.
The Salk biologists “do indeed provide what I believe to be the first evidence that partial reprogramming of the genome ameliorated symptoms of tissue degeneration and improved regenerative capacity,” Dr. Vijg said.

For the full story, see:
NICHOLAS WADE. “Scientists Learn About Human Aging by Lengthening the Life Span of Mice.” The New York Times (Fri., DEC. 16, 2016): A22.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 15, 2016, and has the title “Scientists Say the Clock of Aging May Be Reversible.”)