The Benefits from the Discovery of Sulfa, the First Antibiotic

I quoted a review of The Demon Under the Microscope in an entry from October 12, 2006. I finally managed to read the book, last month.
I don’t always agree with Hager’s interpretation of events, and his policy advice, but he writes well, and he has much to say of interest about how the first anti-bacterial antibiotic, sulfa, was developed.
In the coming weeks, I’ll be highlighting a few key passages of special interest. In today’s entry, below, Hager nicely summarizes the importance of the discovery of antibiotics for his (and my) baby boom generation.

(p. 3) I am part of that great demographic bulge, the World War II “Baby Boom” generation, which was the first in history to benefit from birth from the discovery of antibiotics. The impact of this discovery is difficult to overstate. If my parents came down with an ear infection as babies, they were treated with bed rest, painkillers, and sympathy. If I came down with an ear infection as a baby, I got antibiotics. If a cold turned into bronchitis, my parents got more bed rest and anxious vigilance; I got antibiotics. People in my parents’ generation, as children, could and all too often did die from strep throats, infected cuts, scarlet fever, meningitis, pneumonia, or any number of infectious diseases. I and my classmates survived because of antibiotics. My parents as children, and their parents before them, lost friends and relatives, often at very early ages, to bacterial epidemics that swept through American cities every fall and winter, killing tens of thousands. The suddenness and inevitability of these epidemic deaths, facts of life before the 1930s, were for me historical curiosities, artifacts of another age. Antibiotics virtually eliminated them. In many cases, much-feared diseases of my grandparents’ day—erysipelas, childbed fever, cellulitis—had become so rare they were nearly extinct. I never heard the names.

Source:
Hager, Thomas. The Demon under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor’s Heroic Search for the World’s First Miracle Drug. New York: Three Rivers Press, 2007.

Consumers Bear Costs of Global Warming Policies

CarbonCutsCostsGraph.gif

Source of graph: online version of the WSJ article quoted and cited below.

(p. A10) Leaders of the Group of Eight major industrialized economies, meeting in Japan, issued their first long-term target for cutting global-warming emissions. But their pronouncement failed to address the two toughest questions: How will the world do it, and who will pay?

The answer to the money question is clear: Consumers will pay — at the gasoline pump, at the car dealership and on the monthly electric bill. If the campaign against global warming gets serious, it will transform today’s esoteric environmental threat into a fundamental pocketbook issue for people from Boston to Beijing.

For the full story, see:
JEFFREY BALL. “As Climate Issue Heats Up, Questions of Cost Loom.” The Wall Street Journal (Fri., July 10, 2008): A10.

More Choice is a Robust Result of The Long Tail

I’ve discussed in a previous entry, why The Long Tail is a worthy read. The article quoted below, praises a Harvard Business Review article that disagrees. I haven’t had a chance to read the HBR article yet.
Yet on a fundamental level, I am confident that The Long Tail is right. New technologies such as Amazon and YouTube, reduce the cost of content diversity. If the supply curve of diversity moves right, then (ceteris paribus) the quantity of diverse content will increase. Hence, we can robustly expect more diverse content.
And for us free market libertarians, more choice is good.

(p. B5) The Long Tail theory, as explained by its creator, Wired magazine editor Chris Anderson, holds that society is “increasingly shifting away from a focus on a relatively small number of ‘hits’ (mainstream products and markets) at the head of the demand curve and toward a huge number of niches in the tail.”
The reason involves the abundance of easy choice that the Web makes possible. A record store has room for only a set number of titles. ITunes, though, can link to all of the millions of songs that its servers can store. Thus, said Mr. Anderson, “narrowly-targeted goods and services can be as economically attractive as mainstream fare.” Managers were urged to adopt their business plans accordingly.
Since appearing two years ago, the book has been something of a sacred text in Silicon Valley. Business plans that foresaw only modest commercial prospects for their products cited the Long Tail to justify themselves, as it had apparently proved that the Web allows a market for items besides super-hits. If you demurred, you were met with a look of pity and contempt, as though you had just admitted to still using a Kaypro.
That might now start to change, thanks to the article (online at tinyurl.com/3rg5gp), by Anita Elberse, a marketing professor at Harvard’s business school who takes the same statistically rigorous approach to entertainment and cultural industries that sabermetricians do to baseball.
Prof. Elberse looked at data for online video rentals and song purchases, and discovered that the patterns by which people shop online are essentially the same as the ones from offline. Not only do hits and blockbusters remain every bit as important online, but the evidence suggests that the Web is actually causing their role to grow, not shrink.
Mr. Anderson responded on his Long Tail blog, thelongtail.com, saying much of the difference between his analysis and hers involved how hits and non-hits, or “head” and “tail” in the book’s lingo, are measured. Aside from that, he was generous in praising the article, and said he welcomed the sort of rigorous scrutiny the theory was getting.

For the full commentary, see:
LEE GOMES. “PORTALS; Study Refutes Niche Theory Spawned by Web.” The Wall Street Journal (Weds., JULY 2, 2008): B5.

The full information on The Long Tail, is:
Anderson, Chris. The Long Tail. New York: Hyperion, 2006.

The HBR article that is critical of the long tail, is:
Elberse, Anita. “Should You Invest in the Long Tail?” Harvard Business Review 86, no. 7/8 (2008): 88-96.

The 10 Million Dollar Bookmark and the 35 Billion Dollar Egg

Zimbabwean100BillionDollarNote.jpg “A vendor arranges eggs on a new 100 billion Zimbabwean dollar note in Harare July 22, 2008. Zimbabwe’s central bank introduced new higher-value 100 billion Zimbabwe dollar notes on Monday as part of a desperate fight against spiralling hyperinflation, the bank said. An egg now costs $35 billion.” Source of caption and photo: http://www.daylife.com/photo/03ORa153k8bVA

(p. A1) Robert Mugabe has kept his embattled regime in Zimbabwe afloat on a sea of paper money. Now, he’ll have to try to do it without the paper.

The Munich-based company that has supplied Zimbabwe with the special blank sheets to print its increasingly worthless dollar caved in to pressure on Tuesday from the German government for it to stop doing business with the African ruler.

Mr. Mugabe’s regime relies on a steady supply of the paper — fortified with watermarks and other antiforgery features — to print the bank notes that allow it to pay the soldiers and other loyalists who enable him to stay in power. With an annual inflation rate estimated at well over 1 million percent, new notes with ever more zeros need to be printed every few weeks because the older ones lose their worth so quickly.
. . .
Zimbabwe’s central bank stopped posting inflation figures in January, when it stood at a relatively modest 100,580%. A loaf of bread costs 30 billion Zimbabwean dollars.
. . .
Mr. Mangoma uses a 10 million Zimbabwe dollar bank note, worth 0.0008 of a U.S. cent, as a bookmark because he doesn’t “care if I lose it.”

For the full story, see:
MARCUS WALKER and ANDREW HIGGINS. “Zimbabwe Can’t Paper Over Its Million-Percent Inflation Anymore; Under Pressure, German Company Cuts Off Shipments of Blank Bank Notes to Mugabe.” The Wall Street Journal (Weds., JULY 2, 2008): A1 & A10.
(Note: ellipses added.)

ZimbabweBasketCash.jpg

“Harare produce seller Chipo Chivanze needs a basket of cash to make change because of Zimbabwe’s battered currency.” Source of caption: print version of the WSJ article quoted and cited above. Source of photo: online version of the WSJ article quoted and cited above.

Science Fiction Writers Provide More Accurate Forecasts Than Economists

Robert Fogel, quoted below, is a Nobel-Prize-winning professor of economics at the University of Chicago:

(p. 13) I think I’ve largely covered how things looked after World War II, highlighting both what now seems to have been an unjustified pessimism and also the difficulties in forecasting the future. I close with an anecdote from Simon Kuznets. He used to give a one-year course in growth economics, both at Johns Hopkins and Harvard. One of the points he made was that if you wanted to find accurate forecasts of what happened in the past, don’t look at what the economists said. The economists in 1850 wrote that the progress of the last decade had been so great that it could not possibly continue. And economists at the end of the nineteenth century wrote that the progress of the last half century had been so great that it could not possibly continue during the twentieth century. Kuznets said you would come closest to an accurate forecast if you read the writers of science fiction. But even the writers of science fiction were too pessimistic. Jules Verne recognized that we might eventually get to the moon, but he couldn’t conceive of the technology that actually made the journey possible.

I was at a 2003 conference at Rockefeller University that brought together about 30 people from different disciplines (economics, biology, chemistry, and physics, as well as some industrial leaders) who put forward their views of what was likely to happen in the new millennium. And I must say that the noneconomists were far more bullish than most of the economists I know. So I suspect if we have another MussaFest in 2024, we’ll all look back at how pessimistic we were in 2004.

Source:
Fogel, Robert W. “Reconsidering Expectations of Economic Growth after World War Ii from the Perspective of 2004.” IMF Staff Papers 52 (Special Issue 2005): 6-14.

Good Laws Protect the Innovator

James Burke writes well, and what he writes is often stimulating, and thought-provoking. On the other hand, some of what he writes is exasperating—he writes in sweeping generalities, and often his ‘connections’ are exaggerations, giving no weight (or even mention) to alternative, equally plausible accounts.
But on balance, I enjoy listening to him. Here is one of the bits I especially liked:

(p. 19) Because the rule of law exists, and above all because it encourages and protects acts of innovation with patent legislation, we in the modern world expect that tomorrow will be better than today. Our view of the universe is essentially optimistic because of the marriage between law and innovation. Law gives an individual the confidence to explore, to risk, to venture into the unknown, in the knowledge that he, as an innovator, will be protected by society.

Source:
Burke, James. The Day the Universe Changed: How Galileo’s Telescope Changed the Truth and Other Events in History That Dramatically Altered Our Understanding of the World. Back Bay Books, 1995.

“The Value Conferred on Mankind by the Unknown Inventor of the Plough”

Who will attempt to calculate the value conferred on mankind by the unknown inventor of the plough?

Source:
Say, Jean-Baptiste. A Treatise on Political Economy. Philadelphia: Lippincott, Grambo & Co., 1855; translator C. R. Prinsep, ed. Clement C. Biddle. Fourth-fifth edition.
First published: 1803, in French.
The quotation is from BOOK I, CHAPTER VI “Of Operations Alike Common To All Branches of Industry.”
Full text is posted at: http://www.econlib.org/library/Say/sayT.html
(Note: Say is one of the earliest economists to recognize the importance of entrepreneurs. Today he is best known for his Say’s Law. He lived from 1767-1832.)

When the Ship Is Sinking, Schumpeter Suggests: “Rush to the Pumps”

Wabash economics professor Ben Rogge’s best lecture focused on a question made famous by Schumpeter: “Can Capitalism Survive?” In some ways, Ben’s message was a pessimistic one.
But near the end of his lecture, Rogge included the following quote from Schumpeter’s Capitalism, Socialism and Democracy:

(p. xi) This leads to the charge of “defeatism.” I deny entirely that this term is applicable to a piece of analysis. Defeatism denotes a certain psychic state that has meaning only in relation to action. Facts in themselves and inference from them can never be defeatist or the opposite whatever that might be. The report that a given ship is sinking is not defeatist. Only the spirit in which this report is received can be defeatist: The crew can sit down and drink. But it can also rush to the pumps.

Source of quote:
Schumpeter, Joseph A. Capitalism, Socialism and Democracy. 3rd ed. New York: Harper and Row, 1950.

Reference to Rogge’s collection of essays that includes the title essay mentioned above:
Rogge, Benjamin A. Can Capitalism Survive? Indianapolis: Liberty Fund, Inc., 1979.

“We Will Stay a Laissez-Faire Economy”

AnsipAndrusEstonianPrimeMinister.jpg

“Andrus Ansip, leader of Estonia, an ex-Soviet Republic.” Source of caption and photo: online version of the NYT article quoted and cited below.

An earlier entry suggested that Estonian Prime Minister Andrus Ansip’s support for Steve Forbes’ flat tax, had helped Estonia achieve a high rate of growth.
Apparently there is some sentiment in Estonia to stay the course:

(p. B6) TALLINN, Estonia — For nearly two decades, Estonia embraced capitalism with such gusto that it seemed to be channeling the laissez-faire philosophy of Milton Friedman. From its policies meant to attract foreign investors to its flat tax and freewheeling business culture, it stood out as the former Soviet republic most adept at turning post-Communist chaos into a thriving market economy.
Now Estonians, and some of their Baltic neighbors, are slogging through their first serious economic downturn since liberation from the Soviet grip in the early 1990s.
. . .
Whatever happens, government officials say there will be no betrayal of Friedman’s philosophy. “We will stay a laissez-faire economy,” said Juhan Parts, Estonia’s minister of the economy.
. . .
“I’m an optimist,” said Marje Josing, director of the Estonian Institute for Economic Research. “Fifteen years ago things looked bad, but they managed. A little real-life pressure won’t hurt.”
Indeed, so far the downturn has done little to discourage Estonia’s ambitious entrepreneurs. If anything, it has made them look more avidly elsewhere for growth.
“Estonia may be a small country,” Tarmo Prikk, chief executive of Thulema, an office furniture maker, said with a laugh. “But my ego is bigger.”

For the full story, see:
CARTER DOUGHERTY. “Estonia’s Let-It-Be Economy Is Rattled by Worldwide Distress.” The New York Times (Fri., October 10, 2008): B6.
(Note: ellipses added.)

Obama Plans Big Increases in Many Taxes

TaxPlanComparisonTable.gif

Source of table: online version of the WSJ article quoted and cited below.

(p. A13) When it comes to taxes, the difference between Barack Obama and John McCain is arguably as wide as it’s been in a presidential race since Ronald Reagan and Walter Mondale battled in 1984. Sen. Obama is proposing to raise taxes more than any recent candidate, while Sen. McCain wants to cut them substantially.
. . .
In sum, Mr. Obama is proposing to use the tax code to substantially redistribute income — raising tax rates on a minority of taxpayers to finance tax credits and direct income supplements to millions of others. How much revenue his higher rates would raise depends on how much less those high-earners would work, or how much they would change their practices to shelter their income from those higher rates.
By contrast, Mr. McCain is proposing some kind of tax reduction for most Americans who pay taxes. He says he would finance those cuts by reducing the rate of growth in federal spending.

For the full commentary, see:
Brian M. Carney. “The Election Choice: Taxes.” The Wall Street Journal (Sat., OCTOBER 25, 2008): A13.
(Note: ellipsis added.)