Category: Health

E.U. Regulations Protect Paris Rats

(p. A4) PARIS — On chilly winter mornings, most Parisians hurry by the now-locked square that is home to the beautiful medieval Tour St. Jacques. Only occasionally do they pause, perhaps hearing a light rustle on the fallen leaves or glimpsing something scampering among the dark green foliage.
A bird? A cat? A puppy?
No. A rat.
No. Three rats.
No. Look closer: Ten or 12 rats with lustrous gray-brown coats are shuffling among the dried autumn leaves.
Paris is facing its worst rat crisis in decades. Nine parks and green spaces have been closed either partly or entirely
. . .
In the 19th century, rats terrified and disgusted Parisians who knew that five centuries earlier, the creatures had brought the bubonic plague across the Mediterranean.
The plague ravaged the city, as it did much of Europe, killing an estimated 100,000 Parisians, between a third and half the population at the time. It recurred periodically for four more centuries. Not surprisingly, the experience left Paris with a millennium-long aversion to rodents.
. . .
. . . why are they proliferating? Could it be everybody’s favorite scapegoat — the European Union and its faceless, unaccountable bureaucrats?
Yes, it could.
New regulations from Brussels, the European Union’s headquarters, have forced countries to change how they use rat poison, said Dr. Jean-Michel Michaux, a veterinarian and head of the Urban Animals Scientific and (p. A14) Technical Institute in Paris.
. . .
While the poison could be a risk to human beings, so are the rats — potentially, although no one is suggesting that the bubonic plague is likely to return.

For the full story, see:

ALISSA J. RUBIN. “PARIS JOURNAL; The Rats Came Back. Blame the E,U.” The New York Times (Fri., DEC. 16, 2016): A4 & A14.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 15, 2016, and has the title “PARIS JOURNAL; Rodents Run Wild in Paris. Blame the European Union.”)

Failed “War on Cancer” Gets Repackaged as “Moonshot”

(p. A15) Last Friday [January 8, 2016] a group of 15 cancer researchers cut short a meeting at the Food and Drug Administration. The reason: They had been invited to Vice President Joseph R. Biden’s office to discuss his “moonshot” to cure cancer.
. . .
The idea that a concerted government push can lead to a “cure” for cancer is nearly a half century old, stretching back to President Nixon’s failed “War on Cancer.” The latest, which President Obama formalized in his State of the Union address on Tuesday, has a deeply emotional tinge. Mr. Biden’s son Beau died of brain cancer in May, and the vice president’s very public mourning and call for a “national commitment to end cancer as we know it” as he announced his decision not to run for president has moved and captivated Washington.
. . .
Unlike in 1971, when President Nixon launched his cancer war, researchers now understand that cancer is not one disease but essentially hundreds. The very notion of a single cure — or as Mr. Obama put it, making “America the country that cures cancer once and for all” — is misleading and outdated.
“Cancer is way more complex than anyone had imagined in 1970,” said Dr. Jose Baselga, the president of the American Association for Cancer Research and physician in chief and chief medical officer at Memorial Sloan Kettering Cancer Center.
. . .
Commitments by powerful Washington figures to cure cancer seem to come along about every decade.
Dr. Andrew von Eschenbach, the director of the National Cancer Institute, announced in 2003 that his organization’s goal was to “eliminate suffering and death” caused by cancer by 2015.
During an appropriations hearing, Dr. von Eschenbach got into a public bargaining session with Senator Arlen Specter, then a Republican from Pennsylvania, about how much money Dr. von Eschenbach would need to advance the date of the cure.
“I asked you what it would take to move that date up to 2010,” Mr. Specter asked.
“We have proposed a budget that would support those initiatives that would amount to approximately $600 million a year,” Dr. von Eschenbach answered.
“Six-hundred million a year?” Mr. Specter asked. “And you can move the date from 2015 to 2010?”
“Yes, sir,” Mr. von Eschenbach said.
Mr. Specter died of cancer in 2012.

For the full story, see:
GINA KOLATA and GARDINER HARRIS. “‘Moonshot’ to Cure Cancer, to Be Led by Biden, Relies on Outmoded View of Disease.” The New York Times (Thurs., JAN. 14, 2016): A15.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the story has the date JAN. 13, 2016.)

Prehistoric Hunter Suffered from Ulcer-Causing Microbe

(p. A7) Microbes that once troubled the stomach of a prehistoric hunter known as “Otzi the Iceman,” who died on an Alpine glacier 5,300 years ago, are offering researchers a rare insight into the early settlement of Europe.
In findings reported Thursday [January 7, 2016] in Science, an international research group analyzed remnants of ulcer-causing microbes called Helicobacter pylori exhumed from the well-preserved mummy of the Neolithic nomad. With modern DNA sequencing technology, they reconstructed the genetic structure of this ancient microbe–the oldest known pathogen sequenced so far.
. . .
“We know he had a rough lifestyle,” said Frank Maixner at the European Academy Institute for Mummies and the Iceman in Bolzano, Italy, who led the team of 23 scientists. “We found a lot of pathological conditions.”
. . .
The researchers also determined that the bacteria had inflamed his stomach lining, indicating that the prehistoric hunter, fleeing into the icy highlands where he was shot in the back with an arrow and beaten, may have been feeling ill on the day he was murdered.

For the full story, see:
ROBERT LEE HOTZ. “Iceman’s Gut Sheds Light on Human Migration.” The Wall Street Journal (Fri., Jan. 8, 2016): A7.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the story has the date Jan. 7, 2016, and has the title “Otzi the Iceman’s Stomach Sheds Light on Copper-Age Migration to Europe.”)

The research summarized in the passages quoted above, was more fully reported in:
Maixner, Frank, Ben Krause-Kyora, Dmitrij Turaev, Alexander Herbig, Michael R. Hoopmann, Janice L. Hallows, Ulrike Kusebauch, Eduard Egarter Vigl, Peter Malfertheiner, Francis Megraud, Niall O’Sullivan, Giovanna Cipollini, Valentina Coia, Marco Samadelli, Lars Engstrand, Bodo Linz, Robert L. Moritz, Rudolf Grimm, Johannes Krause, Almut Nebel, Yoshan Moodley, Thomas Rattei, and Albert Zink. “The 5300-Year-Old Helicobacter pylori Genome of the Iceman.” Science 351, no. 6269 (Jan. 8, 2016): 162-65.

Serendipitous Discoveries “Happen in Medicine All the Time”

(p. 18) In the late 1950s, Dr. Jude was a resident at the Johns Hopkins University School of Medicine in Baltimore, experimenting with induced hypothermia as a way to stop blood flow to the heart by cooling it down and allowing surgical procedures to be performed without fatal loss of blood.
In experiments with rats, he found that hypothermia often caused cardiac arrest, a problem that two electrical engineers down the hall were addressing in experimental work on dogs, using a defibrillator to send electrical shocks to the heart. William Kouwenhoven, the inventor of a portable defibrillator, and G. Guy Knickerbocker, a doctoral student, had seen that the mere weight of the defibrillator paddles stimulated cardiac activity when pressed against a dog’s chest.
Dr. Jude immediately saw the potential for human medicine and began working with the two men.
In July 1959, when a 35-year-old woman being anesthetized for a gall bladder operation went into cardiac arrest, Dr. Jude, instead of using the standard technique of opening the chest and massaging the heart directly, applied rhythmic, manual pressure.
“Her blood pressure came back at once,” he recalled. “We didn’t have to open up her chest. They went ahead and did the operation on her, and she recovered completely.”
. . .
Dr. Jude played down his importance in developing CPR, a breakthrough that The Journal of the American Medical Association had recently compared to the discovery of penicillin.
“It was just serendipity — being in the right place at the right time and working on something for which there was an obvious need,” he told the alumni newsletter of the University of St. Thomas in 1984. “Things like that happen in medicine all the time.”

For the full obituary, see:
WILLIAM GRIMES. “Dr. James Jude Dies at 87; Helped Develop Use of CPR.” The New York Times, First Section (Sun., AUG. 2, 2015): 18.
(Note: ellipsis added.)
(Note: the online version of the obituary has the date AUG. 1, 2015, and has the title “Dr. James Jude, Who Helped Develop Use of CPR, Dies at 87.”)

Never Say Die

(p. A7) LONDON — During the last months of her life, a terminally ill 14-year-old British girl made a final wish. Instead of being buried, she asked to be frozen so that she could be “woken up” in the future when a cure was found — even if that was hundreds of years later.
“I want to have this chance,” the teenager wrote in a letter to a judge asking that she be cryogenically preserved. She died on Oct. 17 from a rare form of cancer. “I don’t want to be buried underground,” she wrote.
The girl’s parents, who are divorced, disagreed about the procedure. The teenager had asked the court to designate that her mother, who supported her daughter’s wishes, should decide how to handle her remains.
The judge, Peter Jackson, ruled in her favor. Local news reports said he was impressed by the “valiant way in which she was facing her predicament.” He said she had chosen the most basic preservation option, which costs about £37,000, or nearly $46,000, an amount reportedly raised by her grandparents.
“I want to live and live longer and I think that in the future they might find a cure for my cancer and wake me up,” the teenager wrote in her letter to the judge. Local reports said she had told a relative: “I’m dying, but I’m going to come back again in 200 years.”
. . .
“The scientific theory underlying cryonics is speculative and controversial, and there is considerable debate about its ethical implications,” the judge said in a statement.
“On the other hand, cryopreservation, the preservation of cells and tissues by freezing, is now a well-known process in certain branches of medicine, for example the preservation of sperm and embryos as part of fertility treatment,” the statement said. “Cryonics is cryopreservation taken to its extreme.”
Zoe Fleetwood, the girl’s lawyer, said her client had called Judge Jackson a “hero” after being told of the court’s decision shortly before her death. “By Oct. 6, the girl knew that her wishes were going to be followed,” Ms. Fleetwood told BBC Radio 4. “That gave her great comfort.”

For the full story, see:
KIMIKO DE FREYTAS-TAMURA. “Wish of Girl, 14, to Be Frozen, Is Granted by British Judge.” The New York Times (Sat., NOV. 19, 2016): A7.
(Note: ellipsis added.)
(Note: the online version of the story has the date NOV. 18, 2016, and has the title “Last Wish of Dying Girl, 14, to Be Frozen, Is Granted by Judge.”)

Uncredentialed Loner Saved Lives with Respirator Invention

(p. B9) When the fraternity of inventors celebrate the geniuses who came up with super glue, kitty litter and the cellphone, they sometimes talk about Dr. Bird, an American original who began tinkering with gizmos concocted out of strawberry-shortcake tins and doorknobs and eventually developed four generations of cardiopulmonary devices that came to be widely used in homes and hospitals.
. . .
Dr. Bird was inducted into the National Inventors Hall of Fame in 1995 for developing the first low-cost, mass-produced pediatric respirator, known as the Baby Bird, which has been credited by medical experts with significantly reducing the mortality rates of infants with respiratory problems.
The device, he said, saved two Idaho neighbor boys born with breathing distress. Among those aided by his inventions was his first wife, Mary, who learned she had pulmonary emphysema in 1964; his respirators, including one that used percussion to loosen secretions in her lungs, helped prolong her life until 1986.
Dr. Bird, who received the Presidential Citizens Medal from George W. Bush in 2008 and the National Medal of Technology and Innovation from President Obama in 2009, lived a self-contained but busy life on a remote, 300-acre compound on Lake Pend Oreille, surrounded by majestic mountains and forests 50 miles from the Canadian border.
On the estate was his home; the headquarters of his Percussionaire Corporation, with dozens of employees who develop and market his inventions; a working farm that sustained all the residents; an airfield and hangars for his scores of restored vintage airplanes, seaplanes, helicopters, cars and motorcycles; and the Bird Aviation Museum and Invention Center, which he opened in 2007.
. . .
His first prototype, cobbled together from shortcake tins and a doorknob in 1953, was revised often and tested on volunteer patients with limited success. But in 1958, he introduced the Bird Universal Medical Respirator, a green box that reliably assisted breathing and sold widely to patients and hospitals. He later developed improved versions, as well as his Baby Bird ventilator.
Much of Dr. Bird’s formal higher education came after his successful inventions. His curriculum vitae includes a doctorate in aeronautics in 1977 from Northrop University in Inglewood, and a medical degree in 1979 from the Pontifical Catholic University of Campinas in Brazil.

For the full obituary, see:
ROBERT D. McFADDEN. “Forrest M. Bird, Inventor of Respirators, Dies at 94.” The New York Times (Tues., AUG. 4, 2015): B9.
(Note: ellipses added.)
(Note: the online version of the obituary has the date AUG. 3, 2015, and has the title “Dr. Forrest Bird, Inventor of Medical Respirators and Ventilators, Dies at 94.”)

In Africa Lions “Are Objects of Terror”

(p. A17) Winston-Salem, N.C. — MY mind was absorbed by the biochemistry of gene editing when the text messages and Facebook posts distracted me.
So sorry about Cecil.
Did Cecil live near your place in Zimbabwe?
Cecil who? I wondered. When I turned on the news and discovered that the messages were about a lion killed by an American dentist, the village boy inside me instinctively cheered: One lion fewer to menace families like mine.
My excitement was doused when I realized that the lion killer was being painted as the villain. I faced the starkest cultural contradiction I’d experienced during my five years studying in the United States.
Did all those Americans signing petitions understand that lions actually kill people? That all the talk about Cecil being “beloved” or a “local favorite” was media hype? Did Jimmy Kimmel choke up because Cecil was murdered or because he confused him with Simba from “The Lion King”?
In my village in Zimbabwe, surrounded by wildlife conservation areas, no lion has ever been beloved, or granted an affectionate nickname. They are objects of terror.
. . .
We Zimbabweans are left shaking our heads, wondering why Americans care more about African animals than about African people.
. . .
. . . please, don’t offer me condolences about Cecil unless you’re also willing to offer me condolences for villagers killed or left hungry by his brethren, by political violence, or by hunger.

For the full commentary, see:
GOODWELL NZOU. “In Zimbabwe, We Don’t Cry for Lions.” The New York Times (Weds., AUG. 5, 2015): A17.
(Note: ellipses added.)
(Note: the online version of the commentary has the date AUG. 4, 2015,)

Breakthrough Surgeon “Defied Skepticism”

(p. D8) Dr. Johnson was a reluctant surgeon — early on, he once recalled, “I disliked surgeons and their pompous attitudes” — but he applied the crocheting skills he had learned from his mother, who was a home economics teacher, and the needlecraft he was taught in a seventh-grade sewing class (he got an A), to perform more than 8,500 heart bypass operations over four decades.
. . .
Doctors had experimented with coronary artery surgery since the 1950s, the goal being to remove accumulated plaque caused by cholesterol deposits, which can block blood flow and cause the stabbing pain of angina. One method was to remove the clogged portion of an artery and graft on a replacement patch of cardiac membrane or a segment of vein from a leg.
In 1968, Dr. Johnson and his team took another path, sewing segments of veins from multiple arteries end to end and stitching them directly into the aorta, the body’s main artery, bypassing cardiac ducts where the flow of blood was impeded.
His breakthrough, reported the next year, defied skepticism within the medical profession and heralded a new era of successful double, triple and quadruple bypass surgeries.
“It was perhaps the presentation of Johnson in the spring of 1969 that had the greatest impact on the widespread use” of coronary artery bypass grafting, Dr. Eugene A. Hessel II wrote in “Cardiac Anesthesia: Principles and Clinical Practice,” published in 2001.
To facilitate surgery, Dr. Johnson made another breakthrough by temporarily stopping the heart and slowing the body’s metabolism by cooling and circulating the blood through a heart-lung machine.
. . .
Dr. Johnson’s multiple bypass surgeries, which could take as long as nine hours and were often accompanied by classical music in the operating room, were credited with saving an untold number of lives.
But in an interview with Dr. William S. Stoney for “Pioneers of Cardiac Surgery” (2008), Dr. Johnson said “the single biggest thing I ever did to lower mortality” was to prescribe the drug allopurinol, which is ordinarily used to inhibit the production of uric acid (high levels of it can cause gout), but which has also been found to improve survival in cardiac patients by improving their capacity for exercise.
. . .
“The coronary artery bypass graft operation does nothing for the basic cause of the disease,” Dr. Johnson said, adding, “Prevention is, of course, the ultimate answer.”

For the full obituary, see:
SAM ROBERTS. “W. Dudley Johnson, Heart Bypass Pioneer, Dies at 86.” The New York Times (Mon., OCT. 31, 2016): D8.
(Note: ellipses added.)
(Note: the online version of the obituary has the date OCT. 30, 2016, and has the title “W. Dudley Johnson, Heart Bypass Surgery Pioneer, Dies at 86.”)

Stoney’s book mentioned above, is:
Stoney, William S. Pioneers of Cardiac Surgery. Nashville: Vanderbilt University Press, 2008.

Those Who See, and Fill, Big Unmet Needs Are Often “Weirdos”

(p. A11) . . . “A Truck Full of Money” provides a portrait of a strange, troubled man who happens to be one of the smartest minds in the Route 128 tech corridor.
. . .
The book is being marketed as inspirational, but I found it to be the opposite. No one could read it and become Paul English, or want to. Most tech startups think too small, but the few people with the vision to identify big unmet needs seem to be, for whatever reason, weirdos. The split-second fare comparison that Kayak did is something no human being could do–it requires super-computing–and it has an enormous value, since 8% of the U.S. economy is travel. But once you’ve solved a problem like that, what do you do next?
Paul English hasn’t figured that out, so this book sort of peters out–he may do his once-in-a-lifetime charity project, or he may follow through on Blade–and he has retreated back into the familiar, running a company called Lola that is sort of the opposite of Kayak: It gives you live access to travel concierges. But how could Mr. Kidder’s ending be anything but inconclusive? Mr. English is just 53. Undoubtedly he has another billion-dollar idea nestled in that overactive brainpan, but his investors have to make a leap of faith–that they’ve bet on the right weirdo. God bless these genius geeks, who make our economy leaner by constantly finding more efficient ways to do old things. And God bless the pharmaceutical industry, which protects and preserves them.​

For the full review, see:
JOHN BLOOM. “BOOKSHELF; The Man Who Built Kayak; During one episode of hypomania, Paul English bid $500,000 on an abandoned lighthouse. Recently, he decided to become an Uber driver.” The Wall Street Journal (Thurs., Sept. 27, 2016): A11.
(Note: ellipses added.)
(Note: the online version of the review has the date Sept. 26, 2016.)

The book under review, is:
Kidder, Tracy. A Truck Full of Money: One Man’s Quest to Recover from Great Success. New York: Random House, 2016.

“My Fate Lies with Me, Not with Heaven”

(p. A7) . . . Dr. Unschuld, who is as blunt as he is outspoken, stands at the center of a long and contentious debate in the West over Chinese medicine. For many, it is the ur-alternative to what they see as the industrialized and chemicalized medicine that dominates in the West. For others, it is little more than charlatanism, with its successes attributed to the placebo effect and the odd folk remedy.
Dr. Unschuld is a challenge to both ways of thinking. He has just finished a 28-year English translation of the three principal parts of the foundational work of Chinese medicine: the Huangdi Neijing, or Yellow Emperor’s Inner Classic, published by the University of California Press. But unlike many of the textbooks used in Chinese medicine schools in the West, Dr. Unschuld’s works are monuments to the art of serious translation; he avoids New Age jargon like “energy” or familiar Western medical terms like “pathogens,” seeing both as unfair to the ancient writers and their worldviews.
But this reflects a deep respect for the ancient authors the detractors of Chinese medicine sometimes lack. Dr. Unschuld hunts down obscure terms and devises consistent terminologies that are sometimes not easy to read, but are faithful to the original text. Almost universally, his translations are regarded as trailblazing — making available, for the first time in a Western language, the complete foundational works of Chinese medicine from up to 2,000 years ago.
. . .
. . . then there is the issue of efficacy. With his extremely dry humor, Dr. Unschuld likens Chinese medicine to the herbal formulas of the medieval Christian mystic Hildegard von Bingen. If people want to try it, they should be free to do so, he said, but not at taxpayer expense. As for himself, Dr. Unschuld says he has never tried Chinese medicine.
. . .
His purely academic approach, . . . , makes him a difficult figure for China to embrace. While widely respected for his knowledge and translations, he has done little to advance the government’s agenda of promoting Chinese medicine as soft power. Echoing other critics, he describes China’s translations of the classics as “complete swindles,” saying they are done with little care and only a political goal in mind.
For Dr. Unschuld, Chinese medicine is far more interesting as an allegory for China’s mental state. His most famous book is a history of Chinese medical ideas, in which he sees classic figures, such as the Yellow Emperor, as a reflection of the Chinese people’s deep-seated pragmatism. At a time when demons and ghosts were blamed for illness, these Chinese works from 2,000 years ago ascribed it to behavior or disease that could be corrected or cured.
“It is a metaphor for enlightenment,” he says.
Especially striking, Dr. Unschuld says, is that the Chinese approach puts responsibility on the individual, as reflected in the statement “wo ming zai wo, bu zai tian” — “my fate lies with me, not with heaven.” This mentality was reflected on a national level in the 19th and 20th centuries, when China was being attacked by outsiders. The Chinese largely blamed themselves and sought concrete answers by studying foreign ideas, industrializing and building a modern economy.

For the full story, see:
IAN JOHNSON. “The Saturday Profile; An Expert on Chinese Medicine, but No New Age Healer.” The New York Times (Sat., SEPT. 24, 2016): A7.
(Note: ellipsis added.)
(Note: the online version of the story has the date SEPT. 23, 2016, and has the title “Gandhi the Imperialist – Book Review.”)

The recently finished book mentioned above, is:
Unschuld, Paul U. Huang Di Nei Jing Ling Shu: The Ancient Classic on Needle Therapy. Oakland, CA: University of California Press, 2016.