(p. 5A) PORT-AU-PRINCE, Haiti (AP) — Scientists have presented the strongest evidence yet that U.N. peacekeepers imported the cholera strain that has killed more than 5,500 people in Haiti.
A report published in the July issue of the Emerging Infectious Diseases journal says research findings “strongly suggest” that the U.N. contingent from Nepal contaminated a Haitian river because of poor sanitation at a base. Author Renaud Piarroux had previously blamed peacekeepers. This study is more complete and its methodology was reviewed by other scientists.
Category: Health
Resistance to New Technology
(p. 59) . . . , not everyone was happy with the loss of open hearths. Many people missed the drifting smoke and were convinced they had been healthier when kept “well kippered in wood smoke,” as one observer put it. As late as 1577, a William Harrison insisted that in the days of open fires our heads did never ake.” Smoke in the roof space discouraged nesting birds and was believed to strengthen timbers. Above all, people complained that they weren’t nearly as warm as before, which was true. Because fireplaces were so inefficient, they were constantly enlarged. Some became so enormous that they were built with benches in them, letting people sit inside the fireplace, almost the only place in the house where they could be really warm.
Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
(Note: ellipsis added.)
“People Condemned to Short Lives and Chronic Hardship Are Perhaps Unlikely to Worry Overmuch about Decor”
If “necessity is the mother of invention,” then why did it take so long for someone to invent the louvered slats mentioned at the end of this passage?
(p. 55) In even the best homes comfort was in short supply. It really is extraordinary how long it took people to achieve even the most elemental levels of comfort. There was one good reason for it: life was tough. Throughout the Middle Ages, a good deal of every life was devoted simply to surviving. Famine was common. The medieval world was a world without reserves; when harvests were poor, as they were about one year in four on average, hunger was immediate. When crops failed altogether, starvation inevitably followed. England suffered especially catastrophic harvests in 1272, 1277, 1283, 1292, and 1311, and then an unrelievedly murderous stretch from 1315 to 1319. And this was of course on top of plagues and other illnesses that swept away millions. People condemned to short lives and chronic hardship are perhaps unlikely to worry overmuch about decor. But even allowing for all that, there was just a great, strange slowness to strive for even modest levels of comfort. Roof holes, for instance, let smoke escape, but they also let in rain and drafts until somebody finally, belatedly invented a lantern structure with louvered slats that allowed smoke to escape but kept out rain, birds, and wind. It was a marvelous invention, but by the time it (p. 56) was thought of, in the fourteenth century, chimneys were already coming in and louvered caps were not needed.
Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
Medieval Halls of the Rich Incubated Plague in a Nest of “Filth Unmentionable”
(p. 51) In even the best houses, floors were generally just bare earth strewn with rushes, harboring “spittle and vomit and urine of dogs and men, beer that hath been cast forth and remnants of fishes and other filth unmentionable,” as the Dutch theologian and traveler Desiderius Erasmus rather crisply summarized in 1524. New layers of rushes were laid down twice a year normally, but the old accretions were seldom removed, so that, Erasmus added glumly, “the substratum may be unmolested for twenty years.” The floors were in effect a very large nest, much appreciated by insects and furtive rodents, and a perfect incubator for plague. Yet a deep pile of flooring was generally a sign of prestige. It was common among the French to say of a rich man that he was “waist deep in straw.”
Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
In Medicine, as Elsewhere, What Pays Is Usually What Gets Done
“”I had to train myself not to get too interested in their problems, and not to get sidetracked trying to be a semi-therapist.” Dr. Donald Levin, a psychiatrist whose practice no longer includes talk therapy.” Source of caption and photo: online version of the NYT article quoted and cited below.
(p. A1) DOYLESTOWN, Pa. — Alone with his psychiatrist, the patient confided that his newborn had serious health problems, his distraught wife was screaming at him and he had started drinking again. With his life and second marriage falling apart, the man said he needed help.
But the psychiatrist, Dr. Donald Levin, stopped him and said: “Hold it. I’m not your therapist. I could adjust your medications, but I don’t think that’s appropriate.”
Like many of the nation’s 48,000 psychiatrists, Dr. Levin, in large part because of changes in how much insurance will pay, no longer provides talk therapy, the form of psychiatry popularized by Sigmund Freud that dominated the profession for decades. Instead, he prescribes medication, usually after a brief consultation with each patient. So Dr. Levin sent the man away with a referral to a less costly therapist and a personal crisis unexplored and unresolved.
For the full story, see:
GARDINER HARRIS. “Talk Doesn’t Pay, So Psychiatry Turns Instead to Drug Therapy.” The New York Times, First Section (Sun., March 6, 2011): A1 & A21.
(Note: the online version of the story is dated March 5, 2011.)
Warm Yourself Over a “Dung Fire, and You Will Know What Pollution Really Is”
(p. D4) To the Editor:
The idea that ancient man had fewer tumors because he lived in a less polluted atmosphere (“Unearthing Prehistoric Tumors, and Debate,” Dec. 28) can be held only by those who have limited experience living in a preindustrial way. Try cooking over an open fire burning half-rotten wood, or sitting in a cave warming yourself with a peat or dung fire, and you will know what pollution really is.
Carol Selinske
Rye Brook, N.Y.
Source of NYT letter to the Editor:
Carol Selinske. “LETTERS; Cancer, Then and Now.” The New York Times (Tues., January 4, 2011): D4.
(Note: the online version of the letter is dated: January 3, 2011.)
Laron Syndrome Villagers Free of Cancer and Diabetes, Suggesting Longevity Breakthrough
Source of graph: online version of the NYT article quoted and cited below.
(p. A6) People living in remote villages in Ecuador have a mutation that some biologists say may throw light on human longevity and ways to increase it.
The villagers are very small, generally less than three and a half feet tall, and have a rare condition known as Laron syndrome or Laron-type dwarfism. They are probably the descendants of conversos, Sephardic Jews from Spain and Portugal who were forced to convert to Christianity in the 1490s but were nonetheless persecuted in the Inquisition. They are also almost completely free of two age-related diseases, cancer and diabetes.
A group of 99 villagers with Laron syndrome has been studied for 24 years by Dr. Jaime Guevara-Aguirre, an Ecuadorean physician and diabetes specialist.
. . .
IGF-1 is part of an ancient signaling pathway that exists in the laboratory roundworm as well as in people. The gene that makes the receptor for IGF-1 in the roundworm is called DAF-2. And worms in which this gene is knocked out live twice as long as normal.
The Laron patients have the equivalent defect — their cells make very little IGF-1, so very little IGF-1 signaling takes place, just as in the DAF-2-ablated worms. So the Laron patients might be expected to live much longer.
Because of their striking freedom from cancer and diabetes, they probably could live much longer if they did not have a much higher than usual death rate from causes unrelated to age, like alcoholism and accidents.
. . .
A strain of mice bred by John Kopchick of Ohio University has a defect in the growth hormone receptor gene, just as do the Laron patients, and lives 40 percent longer than usual.
. . .
The longest-lived mouse on record is one studied by Dr. Bartke. It had a defect in its growth hormone receptor gene, just as do the Laron patients. “It missed its fifth birthday by a week,” he said. The mouse lived twice as long as usual and won Dr. Bartke a prize presented by the Methuselah Foundation (which rewards developments in life-extension therapies) in 2003.
For the full story, see:
NICHOLAS WADE. “Ecuadorean Villagers May Hold Secret to Longevity.” The New York Times (Thurs., February 17, 2011): A6.
(Note: ellipses added.)
(Note: the online version of the story is dated February 16, 2011 and has the title “Ecuadorean Villagers May Hold Secret to Longevity.”)
“A 67-year-old man who has Laron-type dwarfism with his daughter, 5, and sons, 7 and 10.” Source of caption and photo: online version of the NYT article quoted and cited below.
The Secret to a Long Life Is Conscientiousness
Source of book image: online version of the NYT review quoted and cited below.
(p. D3) Cheerfulness, optimism, extroversion and sociability may make life more enjoyable, but they won’t necessarily extend it, Howard S. Friedman and Leslie R. Martin found in a study that covered eight decades. The key traits are prudence and persistence. “The findings clearly revealed that the best childhood personality predictor of longevity was conscientiousness,” they write, “the qualities of a prudent, persistent, well-organized person, like a scientist-professor — somewhat obsessive and not at all carefree.”
. . .
There are three explanations for the dominant role of conscientiousness. The first and most obvious is that conscientious people are more likely to live healthy lifestyles, to not smoke or drink to excess, wear seat belts, follow doctors’ orders and take medication as prescribed. Second, conscientious people tend to find themselves not only in healthier situations but also in healthier relationships: happier marriages, better friendships, healthier work situations.
The third explanation for the link between conscientiousness and longevity is the most intriguing. “We thought it must be something biological,” Dr. Friedman said. “We ruled out every other factor.” He and other researchers found that some people are biologically predisposed to be not only more conscientiousness but also healthier. “Not only do they tend to avoid violent deaths and illnesses linked to smoking and drinking,” they write, “but conscientious individuals are less prone to a whole host of diseases, not just those caused by dangerous habits.” The precise physiological explanation is unknown but seems to have to do with levels of chemicals like serotonin in the brain.
As for optimism, it has its downside. “If you’re cheerful, very optimistic, especially in the face of illness and recovery, if you don’t consider the possibility that you might have setbacks, then those setbacks are harder to deal with,” Dr. Martin said. “If you’re one of those people who think everything’s fine — ‘no need to back up those computer files’ — the stress of failure, because you haven’t been more careful, is harmful. You almost set yourself up for more problems.”
For the full review, see:
KATHERINE BOUTO. “BOOKS ON SCIENCE; Eighty Years Along, a Longevity Study Still Has Ground to Cover.” The New York Times (Tues., April 19, 2011): D3.
(Note: ellipsis added.)
(Note: the online version of the article is dated April 18, 2011.)
The book under review is:
Friedman, Howard S., and Leslie R. Martin. The Longevity Project: Surprising Discoveries for Health and Long Life from the Landmark Eight-Decade Study. New York: Hudson Street Press, 2011.
Feds Finally Admit Some Children Harmed by High Fluoridated Water Mandates
WSJ article quoted and cited below.
Back when I was a child, decades ago, my family opposed the fluoridation of public water supplies on the grounds that there might be health risks, and people could individually choose to apply fluoride to their teeth.
Well, now the government is suggesting that too much fluoride can harm children’s teeth, and that the target level for fluoride in the water should be reduced.
(p. A3) The federal government lowered its recommended limit on the amount of fluoride in drinking water for the first time in nearly 50 years, saying that spots on some children’s teeth show they are getting too much of the mineral.
Fluoride has been added to U.S. water supplies since 1945 to prevent tooth decay. Since 1962, the government has recommended adding a range of 0.7 milligrams to 1.2 milligrams per liter.
. . .
A study conducted between 1999 and 2004 by the federal Centers for Disease Control and Prevention found that 41% of children between the ages of 12 and 15 exhibited signs of dental fluorosis, a spotting or streaking on the teeth. That was up from nearly 23% found in a study from 1986 and 1987.
. . .
. . . for years, some groups have called for an end to fluoridation, arguing that it poses serious health dangers, including increased risk of bone fractures and of decreased thyroid function. Friday’s announcement did little to appease such critics.
“The only rational course of action is to stop water fluoridation,” said Paul Connett, executive director of the Fluoride Action Network, a nonprofit advocacy and fluoride-education group
.
For the full story, see:
TIMOTHY W. MARTIN. “Government Advises Less Fluoride in Water.” The Wall Street Journal (Sat., JANUARY 8, 2011): A3.
(Note: ellipses added.)
Patients Face Higher Costs and Less Innovation Due to FDA
“Marti Conger, a business consultant in Benicia, Calif., went to England in October 2009 to get an implant of a new artificial disk for her spine developed by Spinal Kinetics of Sunnyvale, Calif., a short distance from her home.” Source of caption and photo: online version of the NYT article quoted and cited below.
(p. B1) Late last year, Biosensors International, a medical device company, shut down its operation in Southern California, which had once housed 90 people, including the company’s top executives and researchers.
The reason, executives say, was that it would take too long to get its new cardiac stent approved by the Food and Drug Administration.
“It’s available all over the world, including Mexico and Canada, but not in the United States,” said the chief executive, Jeffrey B. Jump, an American who runs the company from Switzerland. “We decided, let’s spend our money in China, Brazil, India, Europe.”
. . .
(p. B7) “Ten years from now, we’ll all get on planes and fly somewhere to get treated,” said Jonathan MacQuitty, a Silicon Valley venture capitalist with Abingworth Management.
Marti Conger, a business consultant in Benicia, Calif., already has. She went to England in October 2009 to get an implant of a new artificial disk for her spine developed by Spinal Kinetics of Sunnyvale, Calif.
“Sunnyvale is 40 miles south of my house,” said Ms. Conger, who has become an advocate for faster device approvals in the United States. “I had to go to England to get my surgery.”
. . .
Device companies have been seeking early approval in Europe for years because it is easier. In Europe, a device must be shown to be safe, while in the United States it must also be shown to be effective in treating a disease or condition. And European approvals are handled by third parties, not a powerful central agency like the F.D.A.
But numerous device executives and venture capitalists said the F.D.A. has tightened regulatory oversight in the last couple of years. Not only does it take longer to get approval but it can take months or years to even begin a clinical trial necessary to gain approval.
Disc Dynamics made seven proposals over three years but could not get clearance from the F.D.A. to conduct a trial of its gel for spine repair, said David Stassen, managing partner of Split Rock Partners, a venture firm that backed the company. “It got to the point where the company just ran out of cash,” Mr. Stassen said. Disc Dynamics was shut down last year after an investment of about $65 million.
For the full story, see:
ANDREW POLLACK. “Medical Treatment, Out of Reach.” The New York Times (Thurs., February 10, 2011): B1 & B7.
(Note: ellipses added.)
(Note: the online version of the story is dated February 9, 2011.)
“An artificial disk like the one Marti Conger received.”
Source of caption and photo: online version of the NYT article quoted and cited above.