Methodology – Page 18 – artdiamondblog.com

Breakthrough Innovations Require Judgment, Not Surveys

Source of book image: http://press.harvardbusiness.org/on/wp-content/uploads/2009/03/verganti_300dpi.jpg.

(p. W8) In “Design-Driven Innovation” (Harvard Business Press, 272 pages, $35), Roberto Verganti holds that product development should be grounded not in the data of survey-takers or the observations of anthropologists but in the judgment of executives. “We have experienced years of hype about user-centered design,” he says. But breakthrough innovations, in Mr. Verganti’s view, do not represent what customers knew they wanted. Rather, the most profitable innovations are those that create a radically new meaning for a product.

Nintendo’s Wii video-game console and its motion-sensing controllers “transformed what a console meant: from an immersion in a virtual world approachable only by niche experts into an active workout, in the real world, for everyone.” The Swatch in 1983 introduced a new meaning to the watch: neither an article of fine jewelry nor a utilitarian timekeeping tool but a fashion accessory. Starbucks, he says, changed the meaning of a coffee shop from a place to buy coffee to a home away from home.

For the full review, see:
DAVID A. PRICE. “The Shape of Things to Come; Design is more than aesthetics and ease of use. It’s a way of doing business.” The Wall Street Journal (Fri., OCTOBER 9, 2009): W8.

Reference for book under review:
Brown, Tim. Change by Design: How Design Thinking Transforms Organizations and Inspires Innovation. New York: HarperBusiness Publishers, 2009.

“A Foolish Faith in Authority Is the Worst Enemy of Truth”

(p. A21) Several years ago I grew concerned about my postmenopausal mother’s risk of osteoporosis. I tried to convince her to initiate hormone replacement therapy. She didn’t listen to me. Instead, she spoke with her gynecologist, who–contrary to best medical evidence at the time–recommended against such treatment. I would eventually be thankful my mother listened to the gynecologist who had known her for decades instead of me and the published medical reviews I was relying on. Some years later my mother was diagnosed with early breast cancer. Had she been on estrogen replacement, it is likely that her tumor would have progressed more rapidly. The gynecologist likely saved my mother’s life.

Studies published in the medical literature are mostly produced by academics who face an imperative to publish or watch their careers perish. These academics aren’t basing their careers on their clinical skills and experiences. Paradoxically, if we allow the academic literature to set guidelines for accepted practices, we are allowing those who are often academics first and clinicians second to determine what clinical care is appropriate.
Consciously or not, those who provide the peer review for medical journals are influenced by whether the work they are reviewing will impact their standing in the medical community. This is a dilemma. The experts who serve as reviewers compete with the work they are reviewing. Leaders in every community, therefore, exert disproportional influence on what gets published. We expect reviewers to be objective and free of conflicts, but in truth, only rarely is that the case.
Albert Einstein once noted that “a foolish faith in authority is the worst enemy of truth.”

For the full commentary, see:

NORBERT GLEICHER. “‘Expert Panels’ Won’t Improve Health Care; Government reliance on medical studies will make it harder to discard false prophecies and dogmas.” The Wall Street Journal (Mon., October 19, 2009): A21.
(Note: the online version of the commentary is dated Sun., Oct. 18.)

Monty Python Success Arose from Freedom, Not Plans

“The unusual suspects, 1969: top row from left, Graham Chapman, Eric Idle and Terry Gilliam; bottom row from left, Terry Jones, John Cleese and Michael Palin.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. 24) “A lot of contemporary comedy seems self-conscious,” Mr. Palin said. “It’s almost documentary, like ‘The Office.’ That’s a very funny show, but you’re looking at the human condition under stress. The Pythons made the human condition seem like fun.”

He added: “I’m proud to be a Python. It’s a badge of silliness, which is quite important. I was the gay lumberjack, I was the Spanish Inquisition, I was one-half of the fish-slapping dance. I look at myself and think that may be the most important thing I’ve ever done.”
Mr. Cleese and Mr. Jones, in rare agreement, both suggested that one reason the Pythons have never been successfully imitated is that television executives nowadays would never let anyone get away with putting together a show like theirs. When they began, they didn’t have an idea what the show should be about or even a title for it. The BBC gave them some money, and then, Mr. Cleese joked, the executives hurried off to the bar.
“The great thing was that in the beginning we had such a low profile,” he said. “We went on at different times, and some weeks we didn’t go on at all, because there might be a show-jumping competition. But that was the key to our feeling of freedom. We didn’t know what the viewing figures were, and we didn’t care. What has happened now is the complete reverse. Even the BBC is obsessed with the numbers.”
So obsessed, Bill Jones pointed out, that in the case of “Monty Python: Almost the Truth” some people encouraged the documentarians to see if they couldn’t squeeze the six hours down to one.

For the full story, see:
CHARLES McGRATH. “Television; On Comedy’s Flying Trapeze.” The New York Times, Arts & Leisure Section (Sun., October 4, 2009): 1 & 24.
(Note: ellipses added.
(Note: the online version of the article is dated September 30, (sic) 2009.)

“Above from left, Mr. Jones, Mr. Gilliam, Mr. Cleese, Mr. Idle and Mr. Palin at the premiere of “Spamalot.”” Source of caption and photo: online version of the NYT article quoted and cited above.

Picking Up Surface Nuggets Versus Digging a Deep Hole in One Place

(p. 423) The work was extraordinarily difficult, pushing the limits of the technically possible. Disappointment is my daily bread, he had said. I thrive on it. But he did not thrive. Often he thought of abandoning the work, abandoning all of it. Yet every day he continued to fill nearly every waking hour with thinking about it. Between 1934 and 1941 he published nothing. Nothing. For a scientist to go through such a dry period is more than depressing. It is a refutation of one’s abilities, of one’s life. But in the midst of that dry spell, Avery told a young researcher there were two types of investigators: most “go around picking up surface nuggets, and whenever they can spot a surface nugget of gold they pick it up and add it to their collection. . . . [The other type] is not really interested in the surface nugget. He is much more interested in digging a deep hole in one place, hoping to hit a vein. And of course if he strikes a vein of gold he makes a tremendous advance.”

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: italics, ellipsis, and brackets, all in original.)

Rapid Mutation of RNA-Based Flu Virus Allows Rapid Adaptation to Immune System Response

I found the passage quoted below to be especially illuminating on how rapid mutation helps explain why the flu virus is so successful and dangerous. (An additional important factor is that the virus can survive in birds, without killing them.)
It occurs to me that something akin to rapid mutation (e.g., rapid experimentation) has also been advocated as a way to quickly advance science (Karl Popper), or enterprise (George Gilder).

(p. 105) Whenever an organism reproduces, its genes try to make exact copies of themselves. But sometimes mistakes–mutations–occur in this process.

This is true whether the genes belong to people, plants, or viruses. The more advanced the organism, however, the more mechanisms exist to prevent mutations. A person mutates at a much slower rate than bacteria, bacteria mutates at a much slower rate than a virus–and a DNA virus mutates at a much slower rate than an RNA virus.
DNA has a kind of built-in proofreading mechanism to cut down on copying mistakes. RNA has no proofreading mechanism whatsoever, no way to protect against mutation. So viruses that use RNA to carry their genetic information mutate much faster–from 10,000 to 1 million times faster–than any DNA virus.
Different RNA viruses mutate at different rates as well. A few mutate so rapidly that virologists consider them not so much a population of copies of the same virus as what they call a “quasi species” or a “mutant swarm.”
These mutant swarms contain trillions and trillions of closely related but different viruses. Even the viruses produced from a single cell will include many different versions of themselves, and the swarm as a whole will routinely contain almost every possible permutation of its genetic code.
Most of these mutations interfere with the functioning of the virus and will either destroy the virus outright or destroy its ability to infect. But other mutations, sometimes in a single base, a single letter, in its genetic code will allow the virus to adapt rapidly to a new situation. It is this adaptability that explains why these quasi species, these mutant swarms, can move rapidly back and forth between different environments and also develop extraordinarily rapid drug resistance. As one investigator has observed, the rapid mutation “confers a certain randomness to the disease processes that accompany RNA [viral] infections.”
Influenza is an RNA virus. So is HIV and the coronavirus. And of all RNA viruses, influenza and HIV are among those that mutate the fastest. The influenza virus mutates so fast that 99 percent of the 100,000 to 1 million new viruses that burst out of a cell in the reproduction process (p. 106) are too defective to infect another cell and reproduce again. But that still leaves between 1,000 and 10,000 viruses that can infect another cell.
Both influenza and HIV fit the concept of a quasi species, of a mutant swarm. In both, a drug-resistant mutation can emerge within days. And the influenza virus reproduces rapidly–far faster than HIV. Therefore it adapts rapidly as well, often too rapidly for the immune system to respond.

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: italics in original.)

Small Evidence Kills Big Theory

Big Tyrannosaurus rex and much smaller Raptorex kriegsteini. Source of image: http://scienceblogs.com/notrocketscience/upload/2009/09/raptorex_tiny_king_of_thieves_shows_how_tyrannosaurus_body_p/Raptorex_Trex.jpg

(p. A5) Paleontologists said Thursday that they had discovered what amounted to a miniature prototype of Tyrannosaurus rex, complete with the oversize head, powerful jaws, long legs — and, as every schoolchild knows, puny arms — that were hallmarks of the king of the dinosaurs.

But this scaled-down version, which was about nine feet long and weighed only 150 pounds, lived 125 million years ago, about 35 million years before giant Tyrannosaurs roamed the earth. So the discovery calls into question theories about the evolution of T. rex, which was about five times longer and almost 100 times heavier.
“The thought was these signature Tyrannosaur features evolved as a consequence of large body size,” Stephen L. Brusatte of the American Museum of National History, an author of a paper describing the dinosaur published online by the journal Science, said at a news conference. “They needed to modify their entire skeleton so they could function as a predator at such colossal size.”
The new dinosaur, named Raptorex kriegsteini, “really throws a wrench into this observed pattern,” Mr. Brusatte said.

For the full story, see:
HENRY FOUNTAIN. “Fossil Discovery Challenges Theories on T. Rex Evolution.” The New York Times (Fri., September 18, 2009): A5.
(Note: the online version is dated Sept. 17th and has the slightly different title: “Fossil Find Challenges Theories on T. Rex” but the body of the article seems the same as the print version.)

Scientist Huxley: “The Great End of Life is Not Knowledge But Action”

John Barry calls our attention to the views of Thomas Huxley who gave the keynote address at the founding of the Johns Hopkins University:

(p. 13) A brilliant scientist, later president of the Royal Society, he advised investigators, “Sit down before a fact as a little child, be prepared to give up every preconceived notion. Follow humbly wherever and to whatever abysses nature leads, or you shall learn nothing.” He also believed that learning had purpose, stating, “The great end of life is not knowledge but action.”

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: from the context in Barry, I am not certain whether the Huxley quotes are from the keynote address, or from elsewhere in Huxley’s writings.)

Economists “Mistook Beauty, Clad in Impressive-Looking Mathematics, for Truth”

Source of caricatures: online version of the NYT article quoted and cited below.

Nobel Prize winner Paul Krugman is no friend of the free market, and more importantly, his manner of dealing with opponents is a long way from gracious civility.
But he is not always completely wrong:

(p. 36) Few economists saw our current crisis coming, . . .
. . .
(p. 37) As I see it, the economics profession went astray because economists, as a group, mistook beauty, clad in impressive-looking mathematics, for truth.

For the full commentary, see:
PAUL KRUGMAN. “How Did Economists Get It So Wrong?.” The New York Times, Magazine Section (Sun., September 2, 2009): 36-43.
(Note: ellipses added.)

The economist on the left is probably intended to resemble Keynes, but he also bears some resemblance to Hayek. Source of caricatures: online version of the NYT article quoted and cited above.

Wikipedia Continues to Gain Respect

(p. B5) Recognizing that the online encyclopedia Wikipedia is increasingly used by the public as a news source, Google News began this month to include Wikipedia among the stable of publications it trawls to create the site.

A visit to the Google News home page on Wednesday evening, for example, found that four of the 30 or so articles summarized there had prominent links to Wikipedia articles, including ones covering the global swine flu outbreak and the Iranian election protests.
. . .
The move by Google News was news to Wikipedia itself. Jay Walsh, a spokesman for the Wikimedia Foundation, said he learned about it by reading an online item on the subject by the Nieman Journalism Lab.
“Google is recognizing that Wikipedia is becoming a source for very up-to-date information,” he said, although “it is an encyclopedia at the end of the day.”

For the full story, see:

NOAM COHEN. “Google Starts Including Wikipedia on Its News Site.” The New York Times Company (Weds., June 22, 2009): B5.
(Note: ellipsis added.)

“The Evidence of His Eyes Overturned 2,000 Years of Accepted Wisdom”

“. . ., the Italian astronomer shows the satellites of Jupiter to Venetian senators in this 1882 illustration.” Source of illustration and caption: online version of the WSJ article quoted and cited below.

(p. A9) A mathematician and experimental physicist, Galileo, however, immediately recognized that what he could see of Venus, Jupiter and the moon through his telescope offered crucial evidence that the sun, not Earth, was the center of our solar system. The evidence of his eyes overturned 2,000 years of accepted wisdom about cosmology in which philosophers had conceived the night sky as a system of crystalline spheres.

Moreover, Galileo quickly shared his observations with scientists throughout Europe by openly publishing his data.
“He wrought a change so fundamental for science and for humanity,” says Munich astronomer Pedro Russo, who is global coordinator of the International Year of Astronomy. “For the first time, we realized we were not the center of the universe.”
But his insistence on contradicting traditional cosmology led to his arrest and trial by the Roman Catholic Church. He was forced to recant his views and imprisoned for life. The Vatican did not formally admit that Galileo was correct until 1992. Now Vatican authorities are planning a statue in his honor.
During his life, Galileo is known to have built at least 100 telescopes, mostly as ornate presentation gifts for his patrons — the powerful Medici family of Florence. Only one is known to survive with its optics intact — the humble device now on show at the Franklin Institute.
“We assume it was personally used by Galileo,” says Paolo Galluzzi, director of the science museum in Florence, which loaned the telescope for the exhibit. “Only this one was found among his property at his death. We believe that this is one of the major tools of his work.”
. . .
“Science is fundamentally about establishing truth for yourself,” says Dr. Pompea in Arizona. “People can make observations, take data and establish for themselves the nature of the universe. They don’t have to take it from someone else or read it in a book.”
Like Galileo, “they can see it.”

For the full story, see:
ROBERT LEE HOTZ. “Galileo’s Discoveries, 400 Years Later, Still Open Eyes
Astronomer’s Telescope, on View Outside Italy for the First Time, Helped Expand Perceptions of the Universe.” The Wall Street Journal (Fri., APRIL 10, 2009): A9.
(Note: ellipsis added.)

“Galileo Galilei.” Source of image and caption: online version of the WSJ article quoted and cited above.