Stem Cell Therapy for Dry Macular Degeneration

SchwartzStevenRetinaSpecialist2012-01-30.jpg

“Dr. Steven Schwartz, a retina specialist at the University of California, Los Angeles, conducted the trial with two patients.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. B7) LOS ANGELES — A treatment for eye diseases that is derived from human embryonic stem cells might have improved the vision of two patients, bolstering the beleaguered field, researchers reported Monday.
The report, published online in the medical journal The Lancet, is the first to describe the effect on patients of a therapy involving human embryonic stem cells.
. . ..
Both patients, who were legally blind, said in interviews that they had gains in eyesight that were meaningful for them. One said she could see colors better and was able to thread a needle and sew on a button for the first time in years. The other said she was able to navigate a shopping mall by herself.
. . .
. . . , researchers at Advanced Cell Technology turned embryonic stem cells into retinal pigment epithelial cells. Deterioration of these retinal cells can lead to damage to the macula, the central part of the retina, and to loss of the straight-ahead vision necessary to recognize faces, watch television or read.
Some 50,000 of the cells were implanted last July under the retinas in one eye of each woman in operations that took about 30 minutes.
One woman, Sue Freeman, who is in her 70s, suffered from the dry form of age-related macular degeneration, a leading cause of severe vision loss in the elderly.

For the full story, see:
ANDREW POLLACK. “Stem Cell Treatment for Eye Diseases Shows Promise.” The New York Times (Thurs., January 26, 2012): B7.
(Note: ellipses added.)
(Note: the online version of the article was dated January 25, 2012.)

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“Sue Freeman said her vision improved in a meaningful way after the treatment, which used embryonic stem cells.” Source of caption and photo: online version of the NYT article quoted and cited above.

California Vegan Defends Freedom to Choose McDonald’s

WarehamEllsworthVegan2012-01-21.jpg “Ellsworth Wareham, 97, in Loma Linda, Calif. Mr. Wareham was a heart surgeon who stopped working only two years ago. He is a vegan, but says choice is part of the “great American system.”” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A15) . . . last week, when the City Council approved Loma Linda’s first McDonald’s restaurant, many residents bemoaned the decision, worrying that the officials were jeopardizing the city’s reputation as a paragon of healthy lifestyles.
. . .
. . . , Dr. Rigsby [said] . . . he would support having a citywide vote on whether fast-food outlets should be banned entirely from the city. “If this is something that people are really opposed to, that’s how we should deal with it.”
What would happen during such a vote is anyone’s guess. Ellsworth Wareham, who stopped working as a heart surgeon only two years ago, at 95, is often used as an example of someone with more energy than someone half his age. Dr. Wareham attributes his health at least partly to the fact that he has been a vegan for the last 30 or 40 years (he does not remember precisely).
Eating at home, he said, is the best way to ensure that one is eating healthy food. He is certainly not about to let the impending arrival of McDonald’s raise his blood pressure.
“I don’t subscribe to the menu that these dear people put out, but let’s face it, the average eating place serves food that is, let us say, a little bit of a higher quality, but the end result is the same — it’s unhealthy,” he said.
“They can put it right next to the church as far as I am concerned,” Dr. Wareham added. “If they choose to eat that way, I’m not going to stop them. That’s the great American system.”

For the full story, see:
JENNIFER MEDINA. “LOMA LINDA JOURNAL; Fast-Food Outlet Stirs Concerns in a Mecca of Healthy Living.” The New York Times (Mon., December 19, 2011): A15.
(Note: ellipses added.)
(Note: the online version of the article is dated December 18, 2011.)

The Case Against Fluoridating Public Water Supplies

(p. A18) Last week, Pinellas County, on Florida’s west coast, voted to stop adding fluoride to its public water supply after starting the program seven years ago. The county joins about 200 jurisdictions from Georgia to Alaska that have chosen to end the practice in the last four years, motivated both by tight budgets and by skepticism about its benefits.
Eleven small cities or towns have opted out of fluoridating their water this year, including Fairbanks, Alaska, which acted after much deliberation and a comprehensive evaluation by a panel of scientists, doctors and dentists. The panel concluded that in Fairbanks, which has relatively high concentrations of naturally occurring fluoride, the extra dose no longer provided the help it once did and may, in fact, be harmful.
. . .
The movement to stop fluoridating water has gained traction, in large part, because the government has recently cautioned the public about excessive fluoride. A report released late last year by the Centers for Disease Control and Prevention linked fluoride to an increase among children in dental fluorosis, which causes white or yellow spots on teeth. About 40 percent of children ages 12 to 15 had dental fluorosis, mostly very mild or mild cases, from 1999 to 2004. That percentage was 22.6 in a 1986-87 study.
Fluorosis is mostly a cosmetic problem that can sometimes be bleached away. But critics argue that spotted teeth are a warning that other bones in the body may be absorbing too much fluoride. Excessive fluoride can lead to increases in bone fractures in adults as well as pain and tenderness.
“Teeth are the window to the bones,” said Paul Connett, a retired professor of environmental chemistry and the director of the Fluoride Action Network, which advocates an end to fluoridated water.
Experts say that one possible factor in this increase may be that fluoridated water is consumed in vegetables and fruit, and juice and other beverages as well as tap water. And the consumption of beverages continues to increase.
. . .
The conclusion among these communities is that with fluoride now so widely available in toothpaste and mouthwash, there is less need to add it to water, which already has naturally occurring fluoride. Putting it in tap water, they say, is an imprecise way of distributing fluoride; how much fluoride a person gets depends on body weight and water consumed.
Doctors, scientists and dentists, including Dr. Bailey of the Public Health Service, mostly agree that fluoride works best when applied topically, directly to the teeth, as happens with brushing.
“The fact that no one really knows what dosage a given person receives from fluoridated water makes the subject of benefits and harms very difficult to quantify,” said Rainer Newberry, a professor of geochemistry at University of Alaska, Fairbanks, who sat on the committee that studied the issue prior to the June vote in Fairbanks. “And this presumably explains the number of studies with diverging conclusions.”

For the full story, see:
LIZETTE ALVAREZ. “Looking to Save Money, More Places Decide to Stop Fluoridating the Water.” The New York Times (Fri., October 14, 2011): A18.
(Note: ellipses added.)
(Note: the online version of the article is dated October 13, 2011.)

Bright Prospects for Longer Life

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Source of book image: online version of the WSJ review quoted and cited below.

(p. A13) “We are at the cusp of a revolution in medicine and biotechnology,” Ms. Arrison announces, “that will radically increase not just our life spans but also, and more importantly, our health spans.”
. . .
She recounts advances in stem-cell research, pharmaceuticals and synthetic biology. And the tinkering with genes still goes on. We learn about Dr. Cynthia Kenyon at the University of California in San Francisco, who discovered that the life span of the tiny worm Caenorhabditis elegans could be doubled by partially disabling a single gene. Further improvements on the technique resulted in worms living six times longer than normal. “In human terms,” Ms. Arrison says, “they be the equivalent of healthy, active five-hundred-year-olds.” That may be a bit much to expect, but Ms. Arrison says she is confident that “human life expectancy will one day reach 150 years.”
. . .
What is more, technology heavyweights are paying attention, including Bill Gates (if he were a teenager today, Mr. Gates once said, he’d be “hacking biology”) and Jeff Bezos (“atom by atom we’ll assemble small machines that will enter cell walls and make repairs”). Larry Ellison, of Oracle, started a foundation more than a decade ago to support anti-aging research; the institution donates about $42 million a year.

For the full review, see:
NICK SCHULZ. “BOOKSHELF; Bioengineering Methuselah; Human beings living to be 150? And you thought Social Security and Medicare were in trouble now.” The Wall Street Journal (Weds., AUGUST 31, 2011): A13.
(Note: ellipses added.)

The book under review is:
Arrison, Sonia. 100 Plus: How the Coming Age of Longevity Will Change Everything, from Careers and Relationships to Family and Faith. New York: Basic Books, 2011.

When Christopher Hitchens Will Visit Nebraska

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“Christopher Hitchens, after being released from the Texas hospital where he was treated for esophageal cancer.” Source of caption and photo: online version of the NYT article quoted and cited below.

A few times I have had the pleasure of seeing Christopher Hitchens interviewed. His wit is always wonderful and he skewers much that deserves skewering. I admire his perseverance at being productive, even as he battles a difficult cancer. And I admire him for sticking to his reasoned principles, even when it might be easier to accept Pascal’s Wager.
I have enjoyed the few reviews by Hitchens that I have read. I have purchased, but not yet read, two of his books—when I have read, I will write.
ADDENDUM: I wrote the above words back on November 10th, scheduled to run today. Yesterday I saw in the paper that Hitchens died on Thursday, December 15, 2011.

(p. C1) HOUSTON — Christopher Hitchens, probably the country’s most famous unbeliever, received the Freethinker of the Year Award at the annual convention of the Atheist Alliance of America here on Saturday. Mr. Hitchens was flattered by the honor, he said a few days beforehand, but also a little abashed. “I think being an atheist is something you are, not something you do,” he explained, adding: “I’m not sure we need to be honored. We don’t need positive reinforcement. On the other hand, we do need to stick up for ourselves, especially in a place like Texas, where they have laws, I think, that if you don’t believe in Jesus Christ you can’t run for sheriff.”

Mr. Hitchens, a prolific essayist and the author of “God Is Not Great: How Religion Poisons Everything,” discovered in June 2010 that he had Stage 4 esophageal cancer.
. . .
(p. C5) On balance, he reflected, the past year has been a pretty good one. He won a National Magazine Award, published “Arguably,” debated Tony Blair in front of a huge audience and added two states to the list of those he has visited. “I lack only the Dakotas and Nebraska,” he said, “though I may not get there unless someone comes up with some ethanol-based cancer treatment in Omaha.”

For the full story, see:
CHARLES McGRATH. “A Voice, Still Vibrant, Reflects on Mortality.” The New York Times (Mon., October 10, 2011): C1 & C5.
(Note: ellipsis added.)

Some Traits (Including Some Diseases) Depend on Many Genes Rather than a Single Gene

(p. D3) A new exploration of how evolution works at the genomic level may have a significant impact on drug development and other areas of medicine.
The report, published in Nature last week, offers new evidence in a longstanding debate about how organisms evolve. One well-known path to change is a heavily favorable mutation in a single gene. But it may be well known only because it is easy to study. Another path is exploitation of mildly favorable differences that already exist in many genes.
. . .
Three biologists at the University of California, Irvine, Molly K. Burke, Michael R. Rose and Anthony D. Long, followed populations of fruit flies through 600 generations and studied the whole genome of some 250 flies in order to see what kinds of genetic change they had undergone.
. . .
The conventional view is that evolutionary change is generally mediated by a favorable mutation in a gene that then washes through the whole population, a process called a hard sweep because all other versions of the gene are brushed away. The alternative, called a soft sweep, is that many genes influence a trait, in this case the rate of maturation, and that the growth-accelerating versions of each of these genes become just a little more common. Each fly has a greater chance of inheriting these growth-promoting versions and so will mature faster.
In sequencing their subjects’ genomes, the researchers found that a soft sweep was indeed responsible for the earlier hatching. No single gene had swept through the population to effect the change; rather, the alternative versions of a large number of genes had become slightly more common.
. . .
Haldane favored the single mutation mechanism, but Fisher and Wright backed multiple gene change.
. . .
The demise of the Haldane view “is very bad news for the pharmaceutical industry in general,” Dr. Rose said. If disease and other traits are controlled by many genes, it will be hard to find effective drugs; a single target would have been much simpler.

For the full story, see:
NICHOLAS WADE. “Natural Selection Cuts Broad Swath Through Fruit Fly Genome.” The New York Times (Tues., September 21, 2010): D3.
(Note: ellipses added.)
(Note: the online version of the article is dated September 20, 2010.)

Global Warming Reduces Bubonic Plague in U.S.

(p. D6) Global warming may have one minor but previously unknown benefit, scientists said this month: it may be cutting down cases of bubonic plague in the United States.
. . .
A study in this month’s issue of The American Journal of Tropical Medicine and Hygiene tracked climatic conditions in 195 counties in 13 Western states, from Washington to Texas, that reported even one plague case since 1950.
Cases have dropped over time, and the study concluded that rising nighttime temperatures since 1990 had helped. Warmer nights melt winter snowpacks earlier, leading to drier soil in rodent burrows. When the soil gets too dry, fleas die.

For the full story, see:
DONALD G. McNEIL Jr. “GLOBAL UPDATE; United States: Decrease in Bubonic Plague Cases May Be an Effect of Climate Change.” The New York Times (Tues., September 21, 2010): D6.
(Note: ellipsis added.)
(Note: the online version of the article is dated September 20, 2010.)

Chocolate Reduces Risk of Cardiovascular Disorder by 37%

(p. D6) An analysis of studies including more than 100,000 subjects has found that high levels of chocolate consumption are associated with a significant reduction in the risk of certain cardiovascular disorders.
. . .
Over all, the report, published Monday in the British medical journal BMJ, showed that those in the group that consumed the most chocolate had decreases of 37 percent in the risk of any cardiovascular disorder and 29 percent in the risk for stroke.

For the full story, see:
NICHOLAS BAKALAR. “VITAL SIGNS; Prevention: Evidence of Heart Benefits From Chocolate.” The New York Times (Tues., August 30, 2011): D6.
(Note: ellipsis added.)
(Note: the online version of the article is dated August 29, 2011.)

“What Happens in America Is Defined by Tort Lawyers”

JungleGymRelic2011-11-09.jpg “CHILDHOOD RELIC; Jungle gyms, like this one in Riverside Park in Manhattan, have disappeared from most American playgrounds in recent decades.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. D3) “There is no clear evidence that playground safety measures have lowered the average risk on playgrounds,” said David Ball, a professor of risk management at Middlesex University in London. He noted that the risk of some injuries, like long fractures of the arm, actually increased after the introduction of softer surfaces on playgrounds in Britain and Australia.

“This sounds counterintuitive, but it shouldn’t, because it is a common phenomenon,” Dr. Ball said. “If children and parents believe they are in an environment which is safer than it actually is, they will take more risks. An argument against softer surfacing is that children think it is safe, but because they don’t understand its properties, they overrate its performance.”
Reducing the height of playground equipment may help toddlers, but it can produce unintended consequences among bigger children. “Older children are discouraged from taking healthy exercise on playgrounds because they have been designed with the safety of the very young in mind,” Dr. Ball said. “Therefore, they may play in more dangerous places, or not at all.”
Fear of litigation led New York City officials to remove seesaws, merry-go-rounds and the ropes that young Tarzans used to swing from one platform to another. Letting children swing on tires became taboo because of fears that the heavy swings could bang into a child.
“What happens in America is defined by tort lawyers, and unfortunately that limits some of the adventure playgrounds,” said Adrian Benepe, the current parks commissioner.

For the full story, see:
JOHN TIERNEY. “FINDINGS; Grasping Risk in Life’s Classroom.” The New York Times (Tues., July 19, 2011): D1 & D3.
(Note: the online version of the article is dated July 18, 2011, and has the title “FINDINGS; Can a Playground Be Too Safe?.”)

No Evidence that Parents Were Ever Indifferent to the Well-Being of Their Children

(p. 404) No one expressed parental loss better (as no one expressed most things better) than William Shakespeare. These lines are from King John, written soon after his son Hamnet died at the age of eleven in 1596:
Grief fills the room up of my absent child
Lies in his bed, walks up and down with me,
Puts on his pretty looks, repeats his words,
Remembers me of all his gracious parts,
Stuffs out his vacant garments with his form.

(p. 405) These are not the words of someone for whom children are a product, and there is no reason to suppose – no evidence anywhere, including that of common sense – that parents were ever, at any point in the past, commonly indifferent to the happiness and well-being of their children. One clue lies in the name of the room in which we are now. ‘Nursery’ is first recorded in English in 1330 and has been in continuous use ever since. A room exclusively dedicated to the needs and comforts of children would hardly seem consistent with the belief that children were of no consequence within the household. No less significant is the word ‘childhood’ itself. It has existed in English for over a thousand years (the first recorded use is in the Lindisfarne Gospels circa AD 950), so whatever it may have meant emotionally to people, as a state of being, a condition of separate existence, it is indubitably ancient. To suggest that children were objects of indifference or barely existed as separate beings would appear to be a simplification at best.

Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
(Note: italics in original.)