Science – Page 28 – artdiamondblog.com

Heretics to the Religion of Global Warming

Source of book image: online version of the WSJ review quoted and cited below.

(p. A19) Suppose for a minute–. . . –that global warming poses an imminent threat to the survival of our species. Suppose, too, that the best solution involves a helium balloon, several miles of garden hose and a harmless stream of sulfur dioxide being pumped into the upper atmosphere, all at a cost of a single F-22 fighter jet.

. . .

The hose-in-the-sky approach to global warming is the brainchild of Intellectual Ventures, a Bellevue, Wash.-based firm founded by former Microsoft Chief Technology Officer Nathan Myhrvold. The basic idea is to engineer effects similar to those of the 1991 mega-eruption of Mt. Pinatubo in the Philippines, which spewed so much sulfuric ash into the stratosphere that it cooled the earth by about one degree Fahrenheit for a couple of years.
Could it work? Mr. Myhrvold and his associates think it might, and they’re a smart bunch. Also smart are University of Chicago economist Steven Levitt and writer Stephen Dubner, whose delightful “SuperFreakonomics”–the sequel to their runaway 2005 bestseller “Freakonomics”–gives Myhrvold and Co. pride of place in their lengthy chapter on global warming. Not surprisingly, global warming fanatics are experiencing a Pinatubo-like eruption of their own.
. . .

. . . , Messrs. Levitt and Dubner show every sign of being careful researchers, going so far as to send chapter drafts to their interviewees for comment prior to publication. Nor are they global warming “deniers,” insofar as they acknowledge that temperatures have risen by 1.3 degrees Fahrenheit over the past century.
But when it comes to the religion of global warming–the First Commandment of which is Thou Shalt Not Call It A Religion–Messrs. Levitt and Dubner are grievous sinners. They point out that belching, flatulent cows are adding more greenhouse gases to the atmosphere than all SUVs combined. They note that sea levels will probably not rise much more than 18 inches by 2100, “less than the twice-daily tidal variation in most coastal locations.” They observe that “not only is carbon plainly not poisonous, but changes in carbon-dioxide levels don’t necessarily mirror human activity.” They quote Mr. Myhrvold as saying that Mr. Gore’s doomsday scenarios “don’t have any basis in physical reality in any reasonable time frame.”
More subversively, they suggest that climatologists, like everyone else, respond to incentives in a way that shapes their conclusions. “The economic reality of research funding, rather than a disinterested and uncoordinated scientific consensus, leads the [climate] models to approximately match one another.” In other words, the herd-of-independent-minds phenomenon happens to scientists too and isn’t the sole province of painters, politicians and news anchors

For the full commentary, see:
BRET STEPHENS. “Freaked Out Over SuperFreakonomics; Global warming might be solved with a helium balloon and a few miles of garden hose.” The Wall Street Journal (Tues., OCTOBER 27, 2009): A19.
(Note: ellipsis added.)

“Every Physicist Wants Two Things: Glory and Money”

(p. 54) . . . in 1950, Shockley published his book Electrons and Holes in Semiconductors, which stood for many years as the definitive work in the field and confirmed his credentials for the Nobel Prize that he shared with Brattain and Bardeen in 1956. The fact was that for his theory of the field effect transistor that later dominated the industry and for the junction transistor that was dominating it at the time, Shockley deserved the prize alone. He had at last made his point.

Yet Shockley was not satisfied. “Every physicist,” he said at the time, “wants two things: glory and money. I have won the glory. Now I want the money.”

Source:

Gilder, George. Microcosm: The Quantum Revolution in Economics and Technology. Paperback ed. New York: Touchstone, 1990.
(Note: ellipsis added.)

Global Warming Did Not Cause Southeast Drought

(p. A13) The drought that gripped the Southeast from 2005 to 2007 was not unprecedented and resulted from random weather events, not global warming, Columbia University researchers have concluded. They say its severe water shortages resulted from population growth more than rainfall patterns.

The researchers, who report their findings in an article in Thursday’s issue of The Journal of Climate, cite census figures showing that in Georgia alone the population rose to 9.54 million in 2007 from 6.48 million in 1990.
“At the root of the water supply problem in the Southeast is a growing population,” they wrote.
Richard Seager, a climate expert at the Lamont-Doherty Earth Observatory who led the study, said in an interview that when the drought struck, “people were wondering” whether climate change linked to a global increase in heat-trapping gases could be a cause.
But after studying data from weather instruments, computer models and measurements of tree rings, which reflect yearly rainfall, “our conclusion was this drought was pretty normal and pretty typical by standards of what has happened in the region over the century,” Mr. Seager said.
Similar droughts unfolded over the last thousand years, the researchers wrote. Regardless of climate change, they added, similar weather patterns can be expected regularly in the future, with similar results.

For the full story, see:
CORNELIA DEAN. “Study Links Water Shortages in Southeast to Population, Not Global Warming.” The New York Times (Fri., October 2, 2009): A13.
(Note: the online version of the article is dated Oct. 1st and has the title “Southeast Drought Study Ties Water Shortage to Population, Not Global Warming.”)

The research summarized in the passages above can be read in its full and original form, at:
Seager, Richard, Alexandrina Tzanova, and Jennifer Nakamura. “Drought in the Southeastern United States: Causes, Variability over the Last Millennium, and the Potential for Future Hydroclimate Change.” Journal of Climate 22, no. 19 (Oct. 1, 2009): 5021-45.

Third Generation Nuclear Reactors Are Simpler and Even Safer

Source of graphic: online version of the WSJ article quoted and cited below.

(p. R1) Researchers are working on reactors that they claim are simpler, cheaper in certain respects, and more efficient than the last generation of plants.

Some designs try to reduce the chance of accidents by automating safety features and minimizing the amount of hardware needed to shut down the reactor in an emergency. Others cut costs by using standardized parts that can be built in big chunks and then shipped to the site. Some squeeze more power out of uranium, reducing the amount of waste produced, while others wring even more energy out of spent fuel.
“Times are exciting for nuclear,” says Ronaldo Szilard, director of nuclear science and engineering at the Idaho National Lab, a part of the U.S. Energy Department. “There are lots of options being explored.”
. . .
(p. R3) As a whole, . . . , the U.S. nuclear industry has a solid safety record, and the productivity of plants has grown dramatically in the past decade. The next generation of reactors so-called Generation III units is intended to take everything that’s been learned about safe operations and do it even better. Generation III units are the reactors of choice for most of the 34 nations that already have nuclear plants in operation. (China still is building a few Gen II units.)
“A common theme of future reactors is to make them simpler so there are fewer systems to monitor and fewer systems that could fail,” says Revis James, director of the Energy Technology Assessment Center at the Electric Power Research Institute, an independent power-industry research organization.
The current generation of nuclear plants requires a complex maze of redundant motors, pumps, valves and control systems to deal with emergency conditions. Generation III plants cut down on some of that infrastructure and rely more heavily on passive systems that don’t need human intervention to keep the reactor in a safe condition reducing the chance of an accident caused by operator error or equipment failure.
For example, the Westinghouse AP1000 boasts half as many safety-related valves, one-third fewer pumps and only one-fifth as much safety-related piping as earlier plants from Westinghouse, majority owned by Toshiba Corp. In an emergency, the reactor, which has been selected for use at Southern Co.’s Vogtle site in Georgia and at six other U.S. locations, is designed to shut down automatically and stay within a safe temperature range.

For the full story, see:
REBECCA SMITH. “The New Nukes; The next generation of nuclear reactors is on its way, and supporters say they will be safer, cheaper and more efficient than current plants. Here’s a look at what’s coming — and when.” The Wall Street Journal (Tues., SEPTEMBER 8, 2009): R1 & R3.
(Note: ellipses added.)

Picking Up Surface Nuggets Versus Digging a Deep Hole in One Place

(p. 423) The work was extraordinarily difficult, pushing the limits of the technically possible. Disappointment is my daily bread, he had said. I thrive on it. But he did not thrive. Often he thought of abandoning the work, abandoning all of it. Yet every day he continued to fill nearly every waking hour with thinking about it. Between 1934 and 1941 he published nothing. Nothing. For a scientist to go through such a dry period is more than depressing. It is a refutation of one’s abilities, of one’s life. But in the midst of that dry spell, Avery told a young researcher there were two types of investigators: most “go around picking up surface nuggets, and whenever they can spot a surface nugget of gold they pick it up and add it to their collection. . . . [The other type] is not really interested in the surface nugget. He is much more interested in digging a deep hole in one place, hoping to hit a vein. And of course if he strikes a vein of gold he makes a tremendous advance.”

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: italics, ellipsis, and brackets, all in original.)

“A Man of Science Past Sixty Does More Harm than Good” (Unless His Name is “Avery”)

(p. 421) . . . , in 1928, Fred Griffith in Britain published a striking and puzzling finding. Earlier Griffith had discovered that all known types of pneumococci could exist with or without capsules. Virulent pneumococci had capsules; pneumococci without capsules could be easily destroyed by the immune system. Now he found something much stranger. He killed virulent pneumococci, ones surrounded by capsules, and injected them into mice. Since the bacteria were dead, all the mice survived. He also injected living pneumococci that had no capsules, that were not virulent. Again the mice lived. Their immune systems devoured the unencapsulated pneumococci. But then he injected dead pneumococci surrounded by capsules and living pneumococci without capsules.
The mice died. Somehow the living pneumococci had acquired cap-(p. 422)sules. Somehow they had changed. And, when isolated from the mice, they continued to grow with the capsule–as if they had inherited it.
Griffith’s report seemed to make meaningless years of Avery’s work– and life. The immune system was based on specificity. Avery believed that the capsule was key to that specificity. But if the pneumococcus could change, that seemed to undermine everything Avery believed and thought he had proved. For months he dismissed Griffith’s work as unsound. But Avery’s despair seemed overwhelming. He left the laboratory for six months, suffering from Graves’ disease, a disease likely related to stress. By the time he returned, Michael Dawson, a junior colleague he had asked to check Griffith’s results, had confirmed them. Avery had to accept them.
His work now turned in a different direction. He had to understand how one kind of pneumococcus was transformed into another. He was now almost sixty years old. Thomas Huxley said, “A man of science past sixty does more harm than good.” But now, more than ever, Avery focused on his task.

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: ellipsis added.)
(Note: italics in original.)

Fossil Found of Much Earlier Human Ancestor

Source of graphic: online version of the NYT article quoted and cited below.

(p. A1) Ardi, short for Ardipithecus ramidus, is the newest fossil skeleton out of Africa to take its place in the gallery of human origins. At an age of 4.4 million years, it lived well before and was much more primitive than the famous 3.2-million-year-old Lucy, of the species Australopithecus afarensis.

Since finding fragments of the older hominid in 1992, an international team of scientists has been searching for more specimens and on Thursday presented a fairly complete skeleton and their first full analysis. By replacing Lucy as the earliest known skeleton from the human branch of the primate family tree, the scientists said, Ardi opened a window to “the early evolutionary steps that our ancestors took after we diverged from our common ancestor with chimpanzees.”
. . .
(p. A6) Scientists not involved in the new research hailed its importance, placing the Ardi skeleton on a pedestal alongside notable figures of hominid evolution like Lucy and the 1.6-million-year-old Turkana Boy from Kenya, an almost complete specimen of Homo erectus with anatomy remarkably similar to modern Homo sapiens.
David Pilbeam, a professor of human evolution at Harvard University who had no role in the discovery, said in an e-mail message that the Ardi skeleton represented “a genus plausibly ancestral to Australopithecus” and began “to fill in the temporal and structural ‘space’ between the apelike common ancestor and Australopithecus.”
Andrew Hill, a paleoanthropologist at Yale University who was also not involved in the research, noted that Dr. White had kept “this skeleton in his closet for the last 15 years or so, but I think it has been worth the wait.” In some ways the specimen’s features are surprising, Dr. Hill added, “but it makes a very satisfactory animal for understanding the changes that have taken place along the human lineage.”
The first comprehensive reports describing the skeleton and related findings, the result of 17 years of study, are being published Friday in the journal Science. Eleven papers by 47 authors from 10 countries describe the analysis of more than 110 Ardipithecus specimens from a minimum of 36 different individuals, including Ardi.
The paleoanthropologists wrote in one of the articles that Ardipithecus was “so rife with anatomical surprises that no one could have imagined it without direct fossil evidence.”
A bounty of animal and plant material — “every seed, every piece of fossil wood, every scrap of bone,” Dr. White said — was gathered to set the scene of the cooler, more humid woodland habitat in which these hominids had lived.
This was one of the first surprises, said Giday WoldeGabriel, a geologist at Los Alamos National Laboratory, because it upset the hypothesis that upright walking had evolved as an adaptation to life on grassy savanna.

For the full story, see:
JOHN NOBLE WILFORD. “Fossil Skeleton From Africa Predates Lucy.” The New York Times (Fri., October 1, 2009): A1 & A6.
(Note: ellipsis added.)

“A fairly complete skeleton of Ardipithecus ramidus, which replaced Lucy as the earliest known skeleton from the human branch of the primate family tree.” Source of caption and photo: online version of the NYT article quoted and cited above.

Harvard Medical School Conference on the Quest for Eternal Life

“AGE WELL. David Sinclair, left, and Christoph Westphal, co-founders of Sitris Pharmaceuticals, in Dr. Sinclair’s laboratory in Cambrdge, Mass. The company develops drugs that mimic resveratrol, a chemical found in some red wines.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. D4) BOSTON — Who would have thought it? The quest for eternal life, or at least prolonged youthfulness, has now migrated from the outer fringes of alternative medicine to the halls of Harvard Medical School.

At a conference on aging held here last week, the medical school’s dean, Jeffrey Flier, was to be seen greeting participants who ranged from members of the 120 club (they intend to live at least that long) to devotees of very low calorie diets.
. . .

Dr. Gallagher said that unpublished tests in mice showed that another chemical mimic, SRT-1720, increased both health and lifespan; after two years, twice as many mice taking the drug were alive compared with the undosed animals. Resveratrol itself has not been shown to increase lifespan in normal mice, although it does so in obese mice, laboratory roundworms and flies.
Sirtris has so far been doubly fortunate. No severe side effects have yet emerged from the clinical trials. The company has also been lucky in having apparently picked the right horse, or at least a good one, in a fast-developing field.
Besides the sirtuins, several other proteins are now known to influence longevity, energy use and the response to caloric restriction. These include the receptors for insulin and for another hormone called IGF-1, and a protein of increasing interest called TOR (“target of rapamycin”). Rapamycin is an antimicrobial that was recently found to extend lifespan significantly, even when given to mice at an advanced age. Since TOR is involved in the response to caloric restriction, rapamycin may extend life through this pathway.
. . .

“In five or six or seven years,” said Christoph Westphal, Sirtris’s other co-founder, “there will be drugs that prolong longevity.”
But neither Dr. Sinclair nor Dr. Westphal was the most optimistic person at the conference. That status belonged to the English gerontologist Aubrey de Grey, who sports a beard so luxuriant that it is hard to see if he is wearing a tie. His goal is “negligible senescence.”
. . .

Sirtris’s quest for longevity drugs is founded on solid and promising research. But most drugs fail at some stage during trials. So there is no guarantee that any of Sirtris’s candidate compounds will work in people. The first result from a Phase 2 clinical trial is not expected until the end of next year at the earliest.
Meanwhile, it is a pleasant and not wholly unfounded thought that, just possibly, a single drug might combat every degenerative disease of Western civilization.

For the full story, see:
NICHOLAS WADE. “Quest for a Long Life Gains Scientific Respect.” The New York Times (Tues., September 28, 2009): D4.
(Note: ellipses added.)

Rapid Mutation of RNA-Based Flu Virus Allows Rapid Adaptation to Immune System Response

I found the passage quoted below to be especially illuminating on how rapid mutation helps explain why the flu virus is so successful and dangerous. (An additional important factor is that the virus can survive in birds, without killing them.)
It occurs to me that something akin to rapid mutation (e.g., rapid experimentation) has also been advocated as a way to quickly advance science (Karl Popper), or enterprise (George Gilder).

(p. 105) Whenever an organism reproduces, its genes try to make exact copies of themselves. But sometimes mistakes–mutations–occur in this process.

This is true whether the genes belong to people, plants, or viruses. The more advanced the organism, however, the more mechanisms exist to prevent mutations. A person mutates at a much slower rate than bacteria, bacteria mutates at a much slower rate than a virus–and a DNA virus mutates at a much slower rate than an RNA virus.
DNA has a kind of built-in proofreading mechanism to cut down on copying mistakes. RNA has no proofreading mechanism whatsoever, no way to protect against mutation. So viruses that use RNA to carry their genetic information mutate much faster–from 10,000 to 1 million times faster–than any DNA virus.
Different RNA viruses mutate at different rates as well. A few mutate so rapidly that virologists consider them not so much a population of copies of the same virus as what they call a “quasi species” or a “mutant swarm.”
These mutant swarms contain trillions and trillions of closely related but different viruses. Even the viruses produced from a single cell will include many different versions of themselves, and the swarm as a whole will routinely contain almost every possible permutation of its genetic code.
Most of these mutations interfere with the functioning of the virus and will either destroy the virus outright or destroy its ability to infect. But other mutations, sometimes in a single base, a single letter, in its genetic code will allow the virus to adapt rapidly to a new situation. It is this adaptability that explains why these quasi species, these mutant swarms, can move rapidly back and forth between different environments and also develop extraordinarily rapid drug resistance. As one investigator has observed, the rapid mutation “confers a certain randomness to the disease processes that accompany RNA [viral] infections.”
Influenza is an RNA virus. So is HIV and the coronavirus. And of all RNA viruses, influenza and HIV are among those that mutate the fastest. The influenza virus mutates so fast that 99 percent of the 100,000 to 1 million new viruses that burst out of a cell in the reproduction process (p. 106) are too defective to infect another cell and reproduce again. But that still leaves between 1,000 and 10,000 viruses that can infect another cell.
Both influenza and HIV fit the concept of a quasi species, of a mutant swarm. In both, a drug-resistant mutation can emerge within days. And the influenza virus reproduces rapidly–far faster than HIV. Therefore it adapts rapidly as well, often too rapidly for the immune system to respond.

Source:
Barry, John M. The Great Influenza: The Story of the Deadliest Pandemic in History. Revised ed. New York: Penguin Books, 2005.
(Note: italics in original.)

Small Evidence Kills Big Theory

Big Tyrannosaurus rex and much smaller Raptorex kriegsteini. Source of image: http://scienceblogs.com/notrocketscience/upload/2009/09/raptorex_tiny_king_of_thieves_shows_how_tyrannosaurus_body_p/Raptorex_Trex.jpg

(p. A5) Paleontologists said Thursday that they had discovered what amounted to a miniature prototype of Tyrannosaurus rex, complete with the oversize head, powerful jaws, long legs — and, as every schoolchild knows, puny arms — that were hallmarks of the king of the dinosaurs.

But this scaled-down version, which was about nine feet long and weighed only 150 pounds, lived 125 million years ago, about 35 million years before giant Tyrannosaurs roamed the earth. So the discovery calls into question theories about the evolution of T. rex, which was about five times longer and almost 100 times heavier.
“The thought was these signature Tyrannosaur features evolved as a consequence of large body size,” Stephen L. Brusatte of the American Museum of National History, an author of a paper describing the dinosaur published online by the journal Science, said at a news conference. “They needed to modify their entire skeleton so they could function as a predator at such colossal size.”
The new dinosaur, named Raptorex kriegsteini, “really throws a wrench into this observed pattern,” Mr. Brusatte said.

For the full story, see:
HENRY FOUNTAIN. “Fossil Discovery Challenges Theories on T. Rex Evolution.” The New York Times (Fri., September 18, 2009): A5.
(Note: the online version is dated Sept. 17th and has the slightly different title: “Fossil Find Challenges Theories on T. Rex” but the body of the article seems the same as the print version.)