Firms Compete in Product Market and Cooperate in Parts Market

(p. B1) When the iPhone X goes on sale next month, Apple Inc.’s rival, Samsung Electronics Co., has good reason to hope it is a roaring success.
The South Korean company’s giant components division stands to make $110 from for each top-of-the-line, $1,000 iPhone X that Apple sells.
The fact reflects a love-hate dynamic between the phone makers that is one of the more unusual relationships in business. While each company vies to get consumers to buy its gadgets, Samsung’s parts operation stands to make billions of dollars supplying screens and memory chips for the new iPhone–parts that Apple relies on for its most important product.

For the full story, see:
Timothy W. Martin and Tripp Mickle. “Samsung To Benefit If iPhone X Is a Success.” The Wall Street Journal (Tues., Oct. 3, 2017): B1 & B5.
(Note: ellipsis, and bracketed date, added.)
(Note: the online version of the story has the date Oct. 2, 2017, and has the title “Why Apple Rival Samsung Also Wins If iPhone X Is a Hit.”)

“Not Prepared to Compromise, in Ill-Considered Conversation, the Greater Truths”

(p. B15) Mr. Pomerance was a somewhat out-of-the-mainstream playwright living in London in 1977 when Foco Novo, a theater company he had founded with Roland Rees and David Aukin, began thinking about staging “The Elephant Man,” based on the true story of Joseph Merrick, a man with severe physical deformities who became a celebrity in Victorian England in the 1880s.
. . .
The resulting play invited theatergoers to contemplate, among many other themes, what is normal and what isn’t.
. . .
Mr. Pomerance was not a talkative sort. “The final impression he gives,” a Times reporter wrote in 1979, “is of a man of considerable intellectual integrity who is not prepared to compromise, in ill-considered conversation, the greater truths he seeks to express on stage.”

For the full obituary, see:
NEIL GENZLINGER. “Bernard Pomerance, 76; Wrote ‘Elephant Man’.” The New York Times (Weds., AUG. 30, 2017): B15.
(Note: ellipses added.)
(Note: the online version of the obituary has the date AUG. 29, 2017, and has the title “Bernard Pomerance, Who Wrote ‘The Elephant Man,’ Dies at 76.”)

Some Bacteria May Promote Cancer

(p. A15) A mysterious bacterium found in up to half of all colon tumors also travels with the cancer as it spreads, researchers reported on Thursday [Nov. 23, 2017].
Whether the bacterium, called Fusobacterium nucleatum, actually plays a role in causing or spurring the growth of cancer is not known. But the new study, published in the journal Science, also shows that an antibiotic that squelches this organism slows the growth of cancer cells in mice.
Scientists are increasingly suspicious that there may be a link: another type of bacteria has been discovered in pancreatic cancer cells. In both types of cancer, most tumors host bacteria; however, only a small proportion of the cells in any single tumor are infected.
“The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon cancer researcher at Johns Hopkins.
The colon cancer story began in 2011, when Dr. Matthew Meyerson of the Dana-Farber Cancer Institute and Dr. Robert A. Holt of Simon Fraser University in British Columbia independently reported finding Fusobacteria, which normally inhabit the mouth, in human colon cancers.
That instigated a rush to confirm. Researchers around the world reported finding Fusobacteria in colon cancers, but their work only raised more questions. The new paper, by Dr. Meyerson and his colleagues, provides some answers.
. . .
Dr. Vogelstein suggests that instead of directly causing cancer, Fusobacteria might be altering patients’ immune response — and perhaps their response to treatments that use the immune system to destroy cancers.
Alternately, perhaps the bacteria are acting more directly by secreting chemicals that spur growth in nearby cancer cells, Dr. Relman said.
“It is not unreasonable to say Fusobacterium is promoting or contributing to colon cancer,” he said.
Are Fusobacteria guilty of causing cancer? If this were a criminal case, where the jury had to be convinced beyond a reasonable doubt, Dr. Meyerson said he would have to acquit.
But if it were a civil case, judged on the preponderance of the evidence, his vote would be different: Fusobacteria are guilty.

For the full story, see:
GINA KOLATA. “Study Suggests Bacteria Have Key Role in Cancer.” The New York Times (Sat., NOV. 25, 2017): A15.
(Note: ellipsis, and bracketed date, added.)
(Note: the online version of the story has the date NOV. 23, 2017, and has the title “Why Is This Bacterium Hiding in Human Tumors?”)

The Science article, discussed in the passages quoted above, is:
Bullman, Susan, Chandra S. Pedamallu, Ewa Sicinska, Thomas E. Clancy, Xiaoyang Zhang, Diana Cai, Donna Neuberg, Katherine Huang, Fatima Guevara, Timothy Nelson, Otari Chipashvili, Timothy Hagan, Mark Walker, Aruna Ramachandran, Begoña Diosdado, Garazi Serna, Nuria Mulet, Stefania Landolfi, Santiago Ramon y Cajal, Roberta Fasani, Andrew J. Aguirre, Kimmie Ng, Elena Élez, Shuji Ogino, Josep Tabernero, Charles S. Fuchs, William C. Hahn, Paolo Nuciforo, and Matthew Meyerson. “Analysis of Fusobacterium Persistence and Antibiotic Response in Colorectal Cancer.” Science (posted online (ahead of publication) on Nov. 23, 2017).

FCC Spectrum Regulations Drive Innovators to Bankruptcy

(p. A17) In 2004 the FCC moved to relax L-Band rules, permitting deployment of a terrestrial mobile network. Satellite calls would continue, but few were being made, and sharing frequencies with cellular devices made eminent sense. By 2010, L-Band licensee LightSquared was ready to build a state-of-the-art 4G network, and the FCC announced that the 40 MHz bandwidth would become available. LightSquared quickly spent about $4 billion of its planned $14 billion infrastructure rollout. Americans would soon enjoy a fifth nationwide wireless choice.
But in 2012 the FCC yanked LightSquared’s licenses. Various interests, from commercial airlines to the Pentagon, complained that freeing up the L Band could cause interference with Global Positioning System devices, since they are tuned to adjacent frequencies. Yet cheap remedies–such as a gradual roll-out of new services while existing networks improved reception with better radio chips–were available. In reality, the costliest spectrum conflicts emanate from overprotecting old services at the expense of the new. With its licenses snatched away, LightSquared instantly plunged into bankruptcy.
. . .
. . . regulatory impediments continue to block progress. Years after the L-Band spectrum was slated for productive use in 4G, it lies fallow–now delaying upgrades to 5G.

For the full commentary, see:
Thomas W. Hazlett. “How Politics Stalls Wireless Innovation; The FCC unveiled its National Broadband Plan in 2010–but couldn’t stick to it.” The Wall Street Journal (Mon., Oct. 2, 2017): A17.
(Note: ellipses added.)
(Note: the online version of the commentary has the date Oct. 1, 2017.)

The commentary, quoted above, is related to the author’s book:
Hazlett, Thomas W. The Political Spectrum: The Tumultuous Liberation of Wireless Technology, from Herbert Hoover to the Smartphone. New Haven, CT: Yale University Press, 2017.

Musk Fires Under-Performing Workers to Speed Output of Mass-Market Electric Sedans

(p. B4) DETROIT — The electric-car maker Tesla fired hundreds of workers this week after a series of performance reviews conducted during the biggest expansion in the company’s history.
Tesla said Friday [Oct. 13, 2017] that the dismissals were not out of the ordinary, even though they came as the automaker tries to increase the production of its first mass-market vehicle, the Model 3 sedan.
The company has been criticized for the slow pace of its early production of the new model, which has generated hundreds of thousands of deposits from prospective buyers.
Tesla built about 25,000 vehicles in the three months that ended Sept. 30, but only 260 of those were Model 3s — considerably fewer than the 1,500 it had projected. The automaker has attributed the low production rate of the new car to unexpected bottlenecks in its manufacturing system.

For the full story, see:
BILL VLASIC. “Tesla Fires Hundreds of Workers.” The New York Times (Sat., OCT. 14, 2017): B4.
(Note: bracketed date added.)
(Note: the online version of the story has the date OCT. 13, 2017, and has the title “Tesla Fires Hundreds as It Tries to Speed Production of an Electric Sedan.”)

Federal and State Mandates Constrain “Creativity in the Classroom”

(p. A11) Mrs. DeVos sees choice as a means to the end of promoting educational innovation–including within traditional public schools. “Instead of focusing on systems and buildings, we should be focused on individual students,” she says. That means encouraging young people “to pursue their curiosity and their interests, and being OK with wherever that takes them–not trying to conform them into a path that everybody has to take.”
What stands in the way? “I think a real robust defense of the status quo is the biggest impediment,” Mrs. DeVos says. She doesn’t mention teachers unions until I raise the subject, whereupon she observes: “I think that they have done a good job in continuing to advocate for their members, but I think it’s a focus more around the needs of adults” rather than students.
Many of the adults are frustrated, too. Recently I met a veteran middle-school teacher who said his creativity in the classroom has been increasingly constrained by federal and state mandates on curriculum and testing. Another teacher I know, who wants to start a charter, complains that “it is getting harder and harder to work for the idiots in traditional schools.”
That sounds familiar to Mrs. DeVos. “I do hear sentiments from many teachers like that,” she says, “and particularly from many teachers that are really effective and creative themselves. I’ve also heard from many teachers who have stopped teaching because they feel like they can’t really be free to do their best, because they’re either subtly or not subtly criticized by peers who might not be as effective as they are–or by administrators who don’t want to see them sort of excelling and upsetting the apple cart within whatever system they’re in.”
She continues: “I talked to a bunch of teachers that had left teaching that had been Teachers of the Year in their states or their counties or whatever. I recall one of the teachers said he just felt so beaten down after being told repeatedly to have his class keep it down–that they were having too much fun, and the kids were too engaged. Well, what kind of a message is that?”

For the full interview, see:
James Taranto, interviewer. “THE WEEKEND INTERVIEW with Betsey DeVos; The Teachers Union’s Public Enemy No. 1.” The Wall Street Journal (Sat., Sept. 2, 2017): A11.
(Note: the online version of the interview has the date Sept. 1, 2017, and has the title “THE WEEKEND INTERVIEW; The Teachers Union’s Public Enemy No. 1.”)

Rate of Inflation Is Still a “Mystery” to Economists

(p. A2) CLEVELAND–Federal Reserve Chairwoman Janet Yellen on Tuesday [Sept. 26, 2017] defended the central bank’s projection for a gradual path of rate increases over the next few years despite the past few months of unexpectedly low inflation.
. . .
Inflation, under the Fed’s preferred measure, has undershot the central bank’s 2% target for much of the past five years. Although Ms. Yellen said she expects inflation to gradually move up to the target, she acknowledged the uncertainty surrounding that prediction.
. . .
“How should policy be formulated in the face of such significant uncertainties? In my view, it strengthens the case for a gradual pace of adjustments,” Ms. Yellen told a National Association for Business Economics conference in Cleveland.
. . .
Still, the Fed’s understanding of inflation is “imperfect,” she said, calling the shortfall in inflation “a mystery.” “We recognize that something more persistent may be responsible for the current undershooting.”

For the full story, see:
David Harrison. “Yellen Firm on Rates; Inflation a ‘Mystery’.” The Wall Street Journal (Weds., Sept. 27, 2017): A2.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the story has the date Sept. 26, 2017, and has the title “Yellen Defends Fed Rate-Rise Plan Despite ‘Mystery’ of Low Inflation.”)

“The Tabula Rasa of the American Dream”

(p. 22) The four Keats siblings, John and George, sister Fanny, and a third brother, “star crossed” Tom, dead of tuberculosis at 19, were all well schooled in the World of Pains. The orphaned children of a shiftless stable hand, they survived on the miserly dole of a tea merchant appointed their guardian. “The lives of these orphans,” Gigante remarks, “do have the makings of fairy tale.” John trained in medicine before taking up the far riskier profession of poetry; reviews of his ambitious long poem “Endymion” were so harsh that Byron cruelly joked he was “snuffed out by an article.” George limped along as a clerk in various mercantile firms, dreaming of something more ­adventurous.
Gigante has had the clever idea of telling the stories of John and George as parallel lives, a dual biography of brothers.
. . .
In her view, George’s departure to America with his young wife, Georgiana, was “an imaginative leap across 4,000 miles onto the tabula rasa of the American dream.” And yet, nothing — nothing, that is, beyond his famous brother — distinguishes George from thousands of other immigrants who joined in the Western migration during the tough years following the French Revolution, when it became painfully clear that possibilities for advancement in class-stratified Great Britain were severely curtailed.
. . .
The land of opportunity was also the land of crushing disappointment. On his second trip to America, after blowing his inheritance on a dubious investment with his elegant friend and neighbor Audubon, and retreating from the bleak prairies to more civilized Louisville, George finally completed his sawmill. (He would have been wiser to invest in Audubon’s pictures of otters and buzzards than a crackpot steamboat scheme.) After a few years of profit, when he built a columned mansion equipped with slaves near the center of town, George lost it all again in the Panic of 1837.

For the full review, see:
CHRISTOPHER BENFEY. “Ode to Siblings.” The New York Times Book Review (Sunday, October 16, 2011): 22.
(Note: ellipses added.)
(Note: the online version of the review has the date OCT. 14, 2011, and has the title “A Keats Brother on the American Frontier.”)

The book under review, is:
Gigante, Denise. The Keats Brothers: The Life of John and George. Cambridge, MA: The Belknap Press of Harvard University Press, 2011.

More Cures If Local Physicians Can Conduct Clinical Trials

(p. A17) The good news is that technology innovations are moving us toward modern clinical trial designs. Electronic health records, now common in U.S. medical practices, allow physicians to collect timely and detailed data that could be used for exploring ways of bringing clinical research directly to patients. Those records are becoming the technological building blocks of a new research model based on real-world evidence, which aims to provide insights regarding the usage and potential benefits or risks of a drug by analyzing patient data collected as part of routine delivery of care.
Real-world evidence captures the experience of real-world patients, who are generally more diverse than the selective cohorts enrolled in clinical trials. Additionally, real-world data from electronic health records may be used after a drug’s approval to answer important questions about its use. Researchers can, for example, search through anonymized data from patients taking a specific cancer drug to see whether those with a certain tumor mutation respond better or worse than other patients. Such information could help doctors personalize therapies based on the patient’s genomic makeup.
Moving clinical research to a doctor’s office, the point of routine care, may also address the difficulties patients and doctors face with off-label drugs. If local physicians can participate in conducting real-world randomized clinical trials in their own practices, new uses of approved drugs could be carefully studied, potentially generating evidence supporting approval of a new use. Real-world clinical trials could also limit disruptions to patients’ lives by reducing the need for long-distance travel.

For the full commentary, see:
Amy Abernethy and Sean Khozin. “Clinical Drug Trials May Be Coming to Your Doctor’s Office; Electronic medical records make possible a new research model based on real-world evidence.” The Wall Street Journal (Weds., Sept. 13, 2017): A17.
(Note: the online version of the commentary has the date Sept. 12, 2017.)

“The Oppressive Communality” of Open Floor Plans

(p. D1) These days, people are taking another look at developing basements or attics as getaway bonus spaces to ensure family peace. As the idea of the open-plan home–the combination kitchen, living and dining room that’s long dominated residential layouts–has aged, it’s revealed its flaws. When parents are relentlessly texting children all day and then corralling the whole family into a single living space all night, there’s no escaping each other, and nerves can fray.
. . .
(p. D2) The oppressive communality of the open plan has fueled the backlash, as has constant connectedness. Jen Altman, a child family psychologist of 17 years, sees the pendulum beginning to swing away from helicopter parenting. These days, she hears parents howl versions of “I just need 10 minutes to myself.”
“I’ve always thought that aloneness and separation are as vital to development as attachment and connection,” said Dr. Altman, who practices in Ho-Ho-Kus, N.J.
. . .
“It’s hard to get away from the open plan because of the way we live,” she said. “It’s the space where everyone congregates–meals are prepared, kids do their homework.” But she found herself seeking respite in the detached room–“sort of an at-home getaway,” she said. Though bright bands of colored paint ring the walls, “the space never reads ‘playroom,'” she said, thanks to a floor of black rocks and shells, and a muted Oriental rug. After Ms. Vidal moved in her beloved midcentury Heywood Wakefield vanity, her design books and mementos made the space hers.
“It’s a bit of separation from being on top of one another,” she said of the room. “It helps me focus.”

For the full story, see:
Elizabeth Anne Hartman. “Hideaway We Go.” The Wall Street Journal (Sat., Aug. 19, 2017): D1-D2.
(Note: ellipses added.)
(Note: the online version of the story has the date Aug. 17, 2017, and has the title “The Open-Floor-Plan Backlash: How Family Members Are Escaping Each Other.”)